Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease

Ventura, Alessandro; Magazzù, Giuseppe; Greco, Luigi

doi:10.1053/gast.1999.0029900297

Cited by 809 publications

(552 citation statements)

References 37 publications

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“…This also may explain why we also diagnosed autonomic dysfunction in 4 of 32 (33.33%) patients, whereas in a recent pilot study we did not find any sign of autonomic dysfunction in CD [28]. The duration of gluten exposure may thus be the key factor to explain our results, and this seems to be confirmed by other data, as the risk of developing autoimmune disorders is higher after long-standing gluten exposure [29,30].…”

Section: Discussionsupporting

confidence: 66%

Peripheral Neurological Disturbances, Autonomic Dysfunction, and Antineuronal Antibodies in Adult Celiac Disease Before and After a Gluten-Free Diet

et al. 2006

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Thirty-two consecutive adult celiac disease (CD) patients (pts), complaining of peripheral neuropathy (12 pts), autonomic dysfunction (17 pts), or both (3 pts), were evaluated to assess the presence of neurological damage (by clinical neurological evaluation and electrophysiological study) and antineuronal antibodies and to assess the effect of a gluten-free diet (GFD) on the course of the neurological symptoms and on antineuronal antibodies. At entry, 12 of 32 (38%) pts showed signs and symptoms of neurological damage: 7 of 12 (58%), peripheral neurological damage; 3 of 12 (25%), autonomic dysfunction; and 2 (17%), both peripheral neurological damage and autonomic dysfunction. The overall TNS score was 105 at entry. Anti-GM1 antibodies were present in 5 of 12 (42%) pts: 3 showed peripheral neurological damage and 2 showed both peripheral neurological damage and autonomic dysfunction. One year after the GFD was started, histological lesions were still present in only 10 of 12 (83%) pts. TNS score was 99, 98, 98, and 101 at the 3rd, 6th, 9th, and 12th month after the GFD was started, so it did not improve throughout the follow-up. None of the pts showed disappearance of antineuronal antibodies throughout the follow-up. We conclude that adult CD patients may show neurological damage and presence of antineuronal antibodies. Unfortunately, these findings do not disappear with a GFD.

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Section: Discussionsupporting

confidence: 66%

Peripheral Neurological Disturbances, Autonomic Dysfunction, and Antineuronal Antibodies in Adult Celiac Disease Before and After a Gluten-Free Diet

et al. 2006

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“…17 An increased prevalence (63%) of coexisting autoimmune conditions was noted in our patients, which is higher than the prevalence reported in celiac disease patients (5-30%). 37,38 This might explain the more pronounced skew in gender distribution, that is, female predominance observed in our series. An association with microscopic colitis, lymphocytic gastritis and/or collagenous gastritis was also seen, the former being more common and occurring at a higher frequency compared with celiac disease patients in general.…”

Section: Discussionmentioning

confidence: 68%

Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients

et al. 2010

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Collagenous sprue is associated with high morbidity; however, the etiology of this disorder is unclear. Data regarding the pathological and clinical manifestations of patients with collagenous sprue are also limited. We, thus, undertook this study to gain insight into the etiology, disease manifestations and outcomes of collagenous sprue. We searched our departmental database (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) to identify cases of collagenous sprue and to obtain clinical and laboratory data. Small bowel histology, including thickness of subepithelial collagen, intra-epithelial lymphocyte phenotype and results of T-cell clonality assays were evaluated. Nineteen patients (15 women, 4 men, age 22-80 years, mean 57 years) were identified.

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“…The higher proportion of children with diarrhea may be related to the younger age at diagnosis reported in their study of 6.5 years, since classical CD tends to present more in the younger age group. Patients with asymptomatic CD, however, are still at risk of complications such as autoimmunity1011 and small-bowel malignancies 12…”

Section: Discussionmentioning

confidence: 99%

Celiac disease in children and adolescents at a singe center in Saudi Arabia

Saadah

2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten in genetically susceptible individuals. The objective of this study was to describe the clinical pattern of CD in children from the western region of Saudi Arabia.DESIGN AND SETTING:Retrospective, hospital-based.PATIENTS AND METHODS:This study included children with a biopsy-proven diagnosis of CD made between September 2002 and July 2007. Children were admitted to the endoscopy unit for a small-bowel biopsy if they had gastrointestinal symptoms suggestive of CD or if they were positive for a CD-antibody screen performed for the high-risk groups.RESULTS:Eighty children were identified with a diagnosis of CD. Their mean (SD) age was 9.6 (4.9) years (range, 0.5-18 years). There were 44 (55%) female patients. Forty-one (51%) patients were detected during screening of high-risk groups, while 39 (49%) patients had classical symptoms of malabsorption. The screening also detected asymptomatic patients. Of 65 patients tested, 11 (17%) had elevated liver function tests, which reverted to normal after introduction of a gluten-free diet (GFD) except in one case. Seventy-three (91%) patients were positive for anti-tissue transglutaminase antibodies, 18 (23%), for IgG anti-gliadin antibodies; and 46 (58%), for IgA anti-gliadin antibodies. Forty-one (56%) patients showed good adherence to GFD as assessed by dietary history and the decline in anti-tTG level.CONCLUSION:CD may present with classical symptoms or be identified through screening programs. Growth and laboratory abnormalities usually improve after introduction of a GFD. Adherence to a GFD remains a problem; therefore, thorough assessment and counseling at the time of diagnosis and ongoing care are crucial.

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Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease

Cited by 809 publications

References 37 publications

Peripheral Neurological Disturbances, Autonomic Dysfunction, and Antineuronal Antibodies in Adult Celiac Disease Before and After a Gluten-Free Diet

Peripheral Neurological Disturbances, Autonomic Dysfunction, and Antineuronal Antibodies in Adult Celiac Disease Before and After a Gluten-Free Diet

Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients

Celiac disease in children and adolescents at a singe center in Saudi Arabia

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