Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs

Abstract

Duration of corneal anesthetic effect induced by topical ophthalmic application of 0.5% proparacaine in dogs of this study is considerably longer than that reported elsewhere. Serial application of doses of 0.5% proparacaine increases the duration and magnitude of corneal anesthetic effects.

Effects of the Ottonia martiana Miq. (Piperaceae) extract on dog's ocular surface

“…Moreover, this information is similar to those reported by Blocker and Van Der Woerdt (2001) in cats and by Brooks et al (2000) in horses. Barret et al (1991) and Herring et al (2005) observed that dolichocephalic dogs exhibit esthesiometry values of 1.75cm, similar to the results obtained in this study (1.7cm). Klaumann (2007) reported values varying from 1.5 to 2.5cm.…”

“…Despite Herring et al (2005) reporting that the proxymetacaine is the drug of choice for ocular surface anesthesia due to its minimal side effects, the manufacturer warns about possible ocular alterations following its administration, such as irritation, conjunctival hyperemia, tearing and corneal erosion.…”

“…The topical anesthetic 0.5% proxymetacaine chloride was added to this study as a comparative variable, due to the frequent use in ophthalmology (Medeiros et al, 2000) and large number of reports regarding its effects (Medeiros et al, 2000;Hamor et al, 2000;Herring et al, 2005;Binder and Herring, 2006). Despite Herring et al (2005) reporting that the proxymetacaine is the drug of choice for ocular surface anesthesia due to its minimal side effects, the manufacturer warns about possible ocular alterations following its administration, such as irritation, conjunctival hyperemia, tearing and corneal erosion.…”

“…A 0 value was admitted when no corneal reflex was observed at a 0.5cm nylon filament length. All tests were performed by the same veterinarian (Herring et al, 2005). Intraocular pressure measurements were performed before treatments (IOPa) and 10 minutes after treatment (IOPb), as suggested by Slatter (2005).…”

“…Procedures like tonometry, corneal sutures and foreign bodies removal, conjunctival biopsies and intracameral injection are only feasible after anesthesia of the ocular surface (Herring et al, 2005). Those substances are used to reduce pain, but its shortterm effect obligates repeated administrations.…”