Duration of antibiotic prophylaxis for cardiac surgery: Prospective observational study

Porat, Eyal E.; Raz, Aeyal; Madar, Hefziba; Fein, Shai; Bishara, Jihad; Biderman, Philippe; Medalion, Benjamin; Sharoni, Erez; Eidelman, Leonid A.; Leibovici, Leonard; Rubinovitch, Bina

doi:10.1016/j.jinf.2009.02.008

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…Post-operative antibiotic prophylaxis is not associated with improved infectious outcomes in patients undergoing cardiac surgery. 11,12 The results of present study suggests that antibiotic prophylaxis has vital role in operative wound infections to reduce the morbidity are in agreement with previous literatures.…”

Section: Discussionsupporting

confidence: 92%

Prospective study on use of antibiotic prophylaxis on operative wound infections in south Indian population

Reddy¹,

Reddy²

2018

Int Surg J

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Background: Antibiotic prophylaxis can help to reduce surgical site infections in operative wound infections. Present work was done to study the use of antibiotic prophylaxis on operative wound infection.Methods: A total of 120 patients under went various surgeries in the department of surgery, Fathima Institute of Medical Sciences, Kadapa, Andhra Pradesh utilized for the present study. Out of 120 patients utilized 86 were males and 34 females with elective surgeries and observed from their admission to discharge from the hospital and also followed up all the patients up to fifth week of post-surgery. Surgical wound types were observed and recorded.Results: We have noted clean wound cases were 91, contaminated cases were 5 and clean contaminated were 24 noted. 11 infected cases were observed in clean wound type, 3 infected cases in clean contaminated were observed. 3 patients out of 120 patients had post-operative fever and subsided within 2 days without antibiotics. Out of 91 clean wound cases, 2 patients (2.19%) had post-operative fever, 10 patients (10.9%) developed with serous discharge and purulent discharge was developed in 1 (1.09%) case in present study. Bacteriology revealed 4 cases (4.29%) showed growth of staphylococcus aureus organism, 1 case (1.09%) with pseudomonas organism was noted. 2 cases (8.3%) developed with serous discharge and 1 case (4.16%) with purulent discharge and also growth of E. coli in 1 (4.16%) case was noted in 24 clean contaminated cases in present study.Conclusions: Use of antibiotic prophylaxis has a vital role in pre and post-operative wound infections.

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Section: Discussionsupporting

confidence: 92%

Prospective study on use of antibiotic prophylaxis on operative wound infections in south Indian population

Reddy¹,

Reddy²

2018

Int Surg J

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“…Furthermore, there are few data on the pharmacokinetics of antibiotics during cardiopulmonary bypass, and therefore dosing regimens are often based on historical practice [ 7 ]. Besides these reasons, results from other trials in cardiac surgery described that increasing the duration of antibiotic prophylaxis in cardiac surgery patients did not result in a significant decrease in surgical site infections [ 3 , 4 , 10 , 20 - 23 ]. Therefore, it is generally accepted that short-term perioperative antibiotic prophylaxis is as efficacious in preventing postoperative complications as longer-term prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Different duration strategies of perioperative antibiotic prophylaxis in adult patients undergoing cardiac surgery: an observational study

Hamouda

Oezkur

Sinha

et al. 2015

J Cardiothorac Surg

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BackgroundAll international guidelines recommend perioperative antibiotic prophylaxis (PAB) should be routinely administered to patients undergoing cardiac surgery. However, the duration of PAB is heterogeneous and controversial.MethodsBetween 01.01.2011 and 31.12.2011, 1096 consecutive cardiac surgery patients were assigned to one of two groups receiving PAB with a second-generation cephalosporin for either 56 h (group I) or 32 h (group II). Patients’ characteristics, intraoperative data, and the in-hospital follow-up were analysed. Primary endpoint was the incidence of surgical site infection (deep and superficial sternal wound-, and vein harvesting site infection; DSWI/SSWI/VHSI). Secondary endpoints were the incidence of respiratory-, and urinary tract infection, as well as the mortality rate.Results615/1096 patients (56,1%) were enrolled (group I: n = 283 versus group II: n = 332). There were no significant differences with regard to patient characteristics, comorbidities, and procedure-related variables. No statistically significant differences were demonstrated concerning primary and secondary endpoints. The incidence of DSWI/SSWI/VHSI were 4/283 (1,4%), 5/283 (1,7%), and 1/283 (0,3%) in group I versus 6/332 (1,8%), 9/332 (2,7%), and 3/332 (0,9%) in group II (p = 0,76/0,59/0,63). In univariate analyses female gender, age, peripheral arterial obstructive disease, operating-time, ICU-duration, transfusion, and respiratory insufficiency were determinants for nosocomial infections (all ≤ 0,05). Subgroup analyses of these high-risk patients did not show any differences between the two regimes (all ≥ 0,05).ConclusionsReducing the duration of PAB from 56 h to 32 h in adult cardiac surgery patients was not associated with an increase of nosocomial infection rate, but contributes to reduce antibiotic resistance and health care costs.

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“…3 Many studies have investigated the optimal duration of perioperative antibiotic prophylaxis in patients undergoing cardiac surgery. 5,[8][9][10][11]20,21 It is generally accepted that short-term perioperative antibiotic prophylaxis is as efficacious in preventing postoperative complications as longer-term prophylaxis, but the optimal duration of antibiotic prophylaxis in cardiac surgery is controversial. 10 The recommendation from the Paul-Ehrlich-Gesellschaft guideline is based on the consensus of the expert panel because the data do not delineate the optimal duration of prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…7 Besides these results, many other reports have noted that increasing the duration of antibiotic prophylaxis in cardiac surgery patients did not result in a significant decrease in surgical site infections. [8][9][10][11] Concerning the international guidelines for antibiotic prophylaxis, there are heterogeneous data. There is no recommendation of singledose administration or for regimen longer than a 48 h. Most guidelines suggest that prophylaxis for 48 h or less may be appropriate for cardiothoracic procedures (evidence level B, class IIa).…”

Section: Introductionmentioning

confidence: 99%

Cardiac surgery antibiotic prophylaxis and calculated empiric antibiotic therapy

Gorski

Hamouda

Özkur

et al. 2014

Asian Cardiovasc Thorac Ann

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Duration of antibiotic prophylaxis for cardiac surgery: Prospective observational study

Cited by 11 publications

References 21 publications

Prospective study on use of antibiotic prophylaxis on operative wound infections in south Indian population

Prospective study on use of antibiotic prophylaxis on operative wound infections in south Indian population

Different duration strategies of perioperative antibiotic prophylaxis in adult patients undergoing cardiac surgery: an observational study

Cardiac surgery antibiotic prophylaxis and calculated empiric antibiotic therapy

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