Duration of Action of Intranasal Atropine on Methacholine-Induced Nasal Secretions

Baroody, Fuad M.; Driscoll, Peter V.; Moylan, Birgitta; Fleming, Leanne; Shilstone, Jonathan; Naclerio, Robert M.

doi:10.1001/archotol.1996.01890150091016

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The blocking effect of the cholinergic antagonist atropine proves that lactoferrin secretion induced by cholinergic stimulation is mediated by specific activation of muscarinic receptors in both the nasal and bronchial mucosa. 5,8,[28][29][30] Beclomethasone dipropionate and budesonide inhibited the spontaneous lactoferrin glandular secretion from both nasal and bronchial explants. Beclomethasone, but not budesonide, showed a more rapid effect on bronchial (at day 1) than nasal mucosa.…”

Section: A B Cmentioning

confidence: 99%

Effects of topical glucocorticoids on in vitro lactoferrin glandular secretion: Comparison between human upper and lower airways

Roca‐Ferrer¹,

Mullol²,

Perez³

et al. 2000

Journal of Allergy and Clinical Immunology

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Section: A B Cmentioning

confidence: 99%

Effects of topical glucocorticoids on in vitro lactoferrin glandular secretion: Comparison between human upper and lower airways

Roca‐Ferrer¹,

Mullol²,

Perez³

et al. 2000

Journal of Allergy and Clinical Immunology

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Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs

Perkins¹,

Pierre²,

Rezk³

et al. 2011

Inhalation Toxicology

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The efficacy of endotracheal aerosolization of atropine sulfate for protection against soman (GD)-induced respiratory toxicity was investigated using microinstillation technique in guinea pigs. GD (841 mg/m(3), 1.3 LCt(50) or 1121 mg/m(3), 1.7 LCt(50)) was aerosolized endotracheally to anesthetized male guinea pigs that were treated with atropine sulfate (5.0 mg/kg) 30 s postexposure by endotracheal microinstillation. Animals exposed to 841 mg/m(3) and 1121 mg/m(3)GD resulted in 31 and 13% while treatment with atropine sulfate resulted in 100 and 50% survival, respectively. Cholinergic symptoms and increased body weight loss were reduced in atropine-treated animals compared to GD controls. Diminished pulse rate and blood O(2) saturation in GD-exposed animals returned to normal levels after atropine treatment. Increased cell death, total cell count and protein in the bronchoalveolar fluid (BALF) in GD-exposed animals returned to normal levels following atropine treatment. GD exposure increased glutathione and superoxide dismutase levels in BALF and that were reduced in animals treated with atropine. Respiratory parameters measured by whole-body barometric plethysmography revealed that treatment with atropine sulfate resulted in normalization of respiratory frequency, tidal volume, time of expiration, time of inspiration, end expiratory pause, pseudo lung resistance (Penh) and pause at 4 and 24 h post 841 mg/m(3) GD exposure. Lung histopathology showed that atropine treatment reduced bronchial epithelial subepithelial inflammation and multifocal alveolar septal edema. These results suggest that endotracheal aerosolization of atropine sulfate protects against respiratory toxicity and lung injury induced by microinstillation inhalation exposure to lethal doses of GD.

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Duration of Action of Intranasal Atropine on Methacholine-Induced Nasal Secretions

Cited by 2 publications

References 12 publications

Effects of topical glucocorticoids on in vitro lactoferrin glandular secretion: Comparison between human upper and lower airways

Effects of topical glucocorticoids on in vitro lactoferrin glandular secretion: Comparison between human upper and lower airways

Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs

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