In modern Western music, melody is commonly conveyed by pitch changes in the highest-register voice, whereas meter or rhythm is often carried by instruments with lower pitches. An intriguing and recently suggested possibility is that the custom of assigning rhythmic functions to lower-pitch instruments may have emerged because of fundamental properties of the auditory system that result in superior time encoding for low pitches. Here we compare rhythm and synchrony perception between low-and high-frequency tones, using both behavioral and EEG techniques. Both methods were consistent in showing no superiority in time encoding for low over high frequencies. However, listeners were consistently more sensitive to timing differences between two nearly synchronous tones when the high-frequency tone followed the low-frequency tone than vice versa. The results demonstrate no superiority of low frequencies in timing judgments but reveal a robust asymmetry in the perception and neural coding of synchrony that reflects greater tolerance for delays of low-relative to high-frequency sounds than vice versa. We propose that this asymmetry exists to compensate for inherent and variable time delays in cochlear processing, as well as the acoustical properties of sound sources in the natural environment, thereby providing veridical perceptual experiences of simultaneity.rhythm perception | time encoding | sound asynchrony perception | auditory perception | mismatch negativity T he perception of music involves the processing of multiple simultaneous sounds, including the perceptual organization of components originating from one instrument into a single "auditory object" (1) and their segregation from components that originate from other instruments. The first stage of this process occurs in the inner ear and involves the decomposition of incoming sound by frequency, resulting in frequency-to-place mapping (tonotopy) along the length of the cochlear partition (2).A series of recent studies has suggested that these and other basic properties of the auditory system, which are shared by a wide variety of species, may help account for some fundamental aspects of Western music, including the dominance of high-register instruments (i.e., instruments with high fundamental frequencies) in carrying the melody (3-7), as well as the dominance of low-register instruments (such as bass or bass drum) in defining the meter or rhythm (8). In the latter case, a study by Hove et al. (8) involving both behavioral and EEG experiments reported that time encoding was superior for low-vs. high-pitched sounds and suggested that this superior time encoding could explain why low instruments generally lay the rhythm in music.The suggestion that superior time encoding of low pitches can explain aspects of Western music is intriguing. However, it runs contrary to the results from studies of many other types of auditory temporal processing, including gap detection (9), amplitude-modulation detection (10) and discrimination (11), and duration discrimination (12)...