Duration and Frequency of Apnea and Frequency of Unconsciousness with Propofol according to Single Injection Dosage

Park, Yong Seok; Choi, Ik Hyun; Kim, Jihee

doi:10.4097/kjae.1997.32.5.829

Cited by 2 publications

(1 citation statement)

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“…However, propofol administration can also result in unstable vital signs such as bradycardia, tachycardia, hypotension, and hypertension [29]. In particular, the use of small doses of propofol for prophylactic purposes after surgery can cause delayed awakening and complications such as hypoxia due to apnea [30]. Thus, the use of propofol to reduce agitation is associated with some limitations [23].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Agitation-Reducing Effects of Esmolol and Lidocaine in Pediatric Strabismus Surgery: A Double-Blind, Randomized Clinical Study

Ji,

Kang,

Seo

et al. 2023

Soonchunhyang Med Sci

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Objective: Agitation is a common symptom in children undergoing surgery, especially when surgeries are performed under sevoflurane and when patients undergo strabismus surgery. Because agitation can increase the risk of falls and lacerations on surgical sites and can delay discharge from the recovery room, adopting measures to reduce the incidence of agitation is essential. This study aimed to compare the agitation-reducing effects of lidocaine and esmolol administered individually or as a combination.Methods: We included 80 patients scheduled to undergo strabismus surgery. Thiopental and sevoflurane were administered to induce general anesthesia. Group EL received lidocaine (2 mg/kg) right after the end of surgery and esmolol (0.5 mg/kg) immediately after recovery from anesthesia after turning the anesthetic gas off; group L received lidocaine at 2 mg/kg right after the end of surgery and did not receive esmolol, group E did not receive lidocaine at the end of the surgery but received esmolol at 0.5 mg/kg right after recovery from anesthesia, and group C received neither esmolol nor lidocaine. Agitation severity was assessed using the objective pain score, Pediatric Anesthesia Emergence Delirium Scale immediately after recovery from anesthesia and until discharge from the recovery room.Results: Groups L and EL showed significantly lower agitation than groups E and C right after recovery from anesthesia, right after arrival to the recovery room, and 10 minutes after arrival to the recovery room (P < 0.05). Groups L and EL showed no differences in the reduction of the severity of agitation (P > 0.05).Conclusion: Compared to the groups without lidocaine administration, groups L and EL, which received 2 mg/kg lidocaine, showed a higher level of reduction in agitation immediately after recovery from anesthesia and right after arrival to the recovery room (P < 0.05).

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Section: Discussionmentioning

confidence: 99%