Dural Venous Sinus Thrombosis in Patients Presenting with Blunt Traumatic Brain Injuries and Skull Fractures: A Systematic Review and Meta-Analysis

Bokhari, Rakan; You, Eunice; Bakhaidar, Mohamad; Bajunaid, Khalid; Lasry, Oliver; Zeiler, Frederick A.; Marcoux, Judith; Baeesa, Saleh

doi:10.1016/j.wneu.2020.06.117

Cited by 24 publications

(22 citation statements)

References 31 publications

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“…Despite lack of anticoagulation, clot resolution was demonstrated shortly afterwards. Regarding the patient whose head injury was complicated by cranial sinus vein thrombosis, it is an increasingly reported complication of traumatic head injury 28 . Interestingly, in a study evaluating traumatic brain injury in FXI‐deficient mice, cerebral thrombogenesis was not reduced by FXI deficiency 29 .…”

Section: Discussionmentioning

confidence: 99%

Pediatric severe factor XI deficiency: A multicenter study

Barg

Levy‐Mendelovich

Budnik

et al. 2021

Pediatric Blood & Cancer

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Background Factor XI (FXI) deficiency is a rare autosomal recessive bleeding disorder. Only scarce publications address its clinical features in children. The increased prevalence of FXI deficiency in Israel enabled data collection for this large multicenter cohort study. Objective Some hemostatic challenges may be unique or more common in children, such as bleeding in the neonatal period or trauma‐related injury. The current study was designed to explore the potential impact of these differences in children with severe FXI deficiency. Methods Medical files of all children with FXI level under 15% followed at five tertiary centers were evaluated. The retrieved data comprised demographic and clinical characteristics, including bleeding episodes, surgical interventions, treatment strategies, as well as laboratory features. Results Sixty children, whose median age at diagnosis was 4.2 years and their median FXI level was 4%, were included. Three children experienced triggered intracranial hemorrhage (ICH) and two children had major bleeds. No bleeding complications occurred in surgeries in which hemostatic treatment consisting mostly of tranexamic acid or fresh frozen plasma was applied (n = 45). In contrast, excessive bleeding was noted in 25% of surgical procedures performed without hemostatic preparation (p = .002). Conclusion This study's findings confirm the generally favorable outcome of this rare bleeding disorder, with no spontaneous bleeds or cases of perinatal ICH. Nonetheless, proper diagnosis and adequate hemostasis in the surgical setting are imperative. Unlike previous studies in adults, our pediatric study suggests an association between the severity of FXI deficiency and bleeding tendency.

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Section: Discussionmentioning

confidence: 99%

Pediatric severe factor XI deficiency: A multicenter study

Barg

Levy‐Mendelovich

Budnik

et al. 2021

Pediatric Blood & Cancer

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“…Because the occurrence of traumatic CVT is usually not immediate, early imaging can miss that. In this context, contrast-enhanced follow-up CT or MR angiography is important to distinguish true thrombosis from sinus narrowing or occlusion caused by a compressing epidural hematoma (12) .…”

Section: Predisposing Factors For Cvtmentioning

confidence: 99%

Cerebral venous thrombosis: imaging patterns

et al. 2022

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Cerebral venous thrombosis (CVT) is an uncommon condition that is potentially reversible if properly diagnosed and promptly treated. Although CVT can occur at any age, it most commonly affects neonates and young adults. Clinical diagnosis is difficult because the clinical manifestations of CVT are nonspecific, including headache, seizures, decreased level of consciousness, and focal neurologic deficits. Therefore, imaging is crucial for the diagnosis. Radiologists should be able to identify the findings of CVT and to recognize potential imaging pitfalls that may lead to misdiagnosis. Thus, the appropriate treatment (anticoagulation therapy) can be started early, thereby avoiding complications and unfavorable outcomes.

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“…In children with BDs, there are no standard guidelines that direct management of thrombosis 4 . Literature regarding the treatment of CSVT is variable, with studies demonstrating good neurological outcomes and thrombus resolution without anticoagulation therapy as well as studies indicating CSVT propagation in over 1/3 of children not treated with anticoagulation therapy [5][6][7] . Here we present the management and outcome of four children with inherited BDs who developed trauma related CSVT.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Sinus Venous Thrombosis in Children with Inherited Bleeding Disorders -- a Case Series

Sheikh

Srivaths

et al. 2022

Preprint

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In patients with inherited bleeding disorders, thrombus development poses a challenge in balancing the management of thrombosis and bleeding. Pediatric antithrombotic therapy guidelines do not address the treatment of a thrombus in the setting of a bleeding disorder. We present a case series of four children with inherited bleeding disorders presenting with cerebral sinus venous thrombosis and bleeding, in order to summarize the different therapeutic approaches and outcomes of these patients.

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Dural Venous Sinus Thrombosis in Patients Presenting with Blunt Traumatic Brain Injuries and Skull Fractures: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 31 publications

Pediatric severe factor XI deficiency: A multicenter study

Pediatric severe factor XI deficiency: A multicenter study

Cerebral venous thrombosis: imaging patterns

Cerebral Sinus Venous Thrombosis in Children with Inherited Bleeding Disorders -- a Case Series

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