Abstract:Dural sinus thrombosis (DST), or cerebral venous thrombosis, is an uncommon cause of stroke. It has a variable presentation, and the symptoms and signs can be non-specific. The diagnosis of DST can be difficult to make and is often delayed or missed. Computed tomography venography or magnetic resonance venography are the typical imaging modalities used to diagnose DST. However, computed tomography venography and magnetic resonance venography both have limitation for emergency department patients. In this artic… Show more
“…It is noteworthy that the use of non-invasive (including ultrasound) techniques in the AHA/ASA 2018 recommendations is considered preferable in cases where the subsequent implementation of mechanical thromboextraction is not implied, while the use of multimodal (using MSCT and MRI) approach to the diagnosis of stroke is not recommended due to a possible delay in the decision to perform thrombolytic therapy (Class III, level of evidence B, randomized trials is no exist) [30]. Assessment of velocity parameters in the Galen vein and Rosenthal veins during transcranial scanning is an additional indirect sign of intracranial venous stasis, but the use of the method is limited by the absence of an acoustic window according to various data in 10-20% of cases [31][32][33]. The use of ultrasonic IAVR (within the protocol of color duplex scanning of brachiocephalic vessels), as well as the assessment of headache intensity according to the visual analogue scale in the developed model, improve the quality of early diagnosis of acute ischemic stroke and get the predicted likelihood of a patient having a venous stroke without the need for the cumbersome formula presented above.…”
Identification of signs of intracranial venous stasis using ultrasound methods in combination with determination of headache intensity according to the visual-analogue scale allows us to suspect the venous genesis of ischemic stroke before using neuroimaging methods, which can contribute to the selection of adequate therapy and to improve the prognosis and long-term outcomes of the disease. Objective: To study the prognostic value of a complex of clinical demographic and instrumental indicators for developing a model for early differential diagnosis of ischemic stroke of arterial and venous origin. Material and Methods: Examined 124 patients with ischemic stroke: 22 with venous stroke due cerebral venous sinus thrombosis (VIS), 53.5±16.7y and 102 with atherothrombotic stroke (AIS), 68.3±12.1y which were verified by native CT; CT-angiography, PCT (perfusion CT: CBF, CBV, MTT), brachiocephalic vessels ultrasound index of arteriovenous ratio (IAVR) and transcranial duplex scanning for all. IAVR was obtained due duplex scanning of carotid common arteries (CCA) and internal jugular veins (IJV) according to the formula: V max IJV optimal =2S CCA × Vps CCA/ 3S IJV……… (1) IAVR = max IJV actual / V max IJV optimal × 100%, where……… (2) IAVR-index of arteriovenous ratio, (%) Vps CCA-peak systolic velocity of the CCA, cm/s Vmax IJV-maximum blood flow velocity, cm/s. S-vessel cross-sectional area, cm 2 , as well as. To assess the neurological status of patients, rating scales were used, including a visually analog headache intensity scale. Results: The greatest prognostic significance was possessed by such parameters as the indicator of arteriovenous blood flow ratio and the value of headache intensity on a visual-analogue scale. A model for the differential diagnosis of AIS and VIS, which has high specificity and sensitivity, has been developed. Velocity indicators in the veins of Rosenthal and the vein of Galen are additional signs of intracranial venous stasis.
“…It is noteworthy that the use of non-invasive (including ultrasound) techniques in the AHA/ASA 2018 recommendations is considered preferable in cases where the subsequent implementation of mechanical thromboextraction is not implied, while the use of multimodal (using MSCT and MRI) approach to the diagnosis of stroke is not recommended due to a possible delay in the decision to perform thrombolytic therapy (Class III, level of evidence B, randomized trials is no exist) [30]. Assessment of velocity parameters in the Galen vein and Rosenthal veins during transcranial scanning is an additional indirect sign of intracranial venous stasis, but the use of the method is limited by the absence of an acoustic window according to various data in 10-20% of cases [31][32][33]. The use of ultrasonic IAVR (within the protocol of color duplex scanning of brachiocephalic vessels), as well as the assessment of headache intensity according to the visual analogue scale in the developed model, improve the quality of early diagnosis of acute ischemic stroke and get the predicted likelihood of a patient having a venous stroke without the need for the cumbersome formula presented above.…”
Identification of signs of intracranial venous stasis using ultrasound methods in combination with determination of headache intensity according to the visual-analogue scale allows us to suspect the venous genesis of ischemic stroke before using neuroimaging methods, which can contribute to the selection of adequate therapy and to improve the prognosis and long-term outcomes of the disease. Objective: To study the prognostic value of a complex of clinical demographic and instrumental indicators for developing a model for early differential diagnosis of ischemic stroke of arterial and venous origin. Material and Methods: Examined 124 patients with ischemic stroke: 22 with venous stroke due cerebral venous sinus thrombosis (VIS), 53.5±16.7y and 102 with atherothrombotic stroke (AIS), 68.3±12.1y which were verified by native CT; CT-angiography, PCT (perfusion CT: CBF, CBV, MTT), brachiocephalic vessels ultrasound index of arteriovenous ratio (IAVR) and transcranial duplex scanning for all. IAVR was obtained due duplex scanning of carotid common arteries (CCA) and internal jugular veins (IJV) according to the formula: V max IJV optimal =2S CCA × Vps CCA/ 3S IJV……… (1) IAVR = max IJV actual / V max IJV optimal × 100%, where……… (2) IAVR-index of arteriovenous ratio, (%) Vps CCA-peak systolic velocity of the CCA, cm/s Vmax IJV-maximum blood flow velocity, cm/s. S-vessel cross-sectional area, cm 2 , as well as. To assess the neurological status of patients, rating scales were used, including a visually analog headache intensity scale. Results: The greatest prognostic significance was possessed by such parameters as the indicator of arteriovenous blood flow ratio and the value of headache intensity on a visual-analogue scale. A model for the differential diagnosis of AIS and VIS, which has high specificity and sensitivity, has been developed. Velocity indicators in the veins of Rosenthal and the vein of Galen are additional signs of intracranial venous stasis.
“…Transcranial duplex scanning is usually performed upon admission to the hospital. Assessment of velocity parameters in the Galen vein and Rosenthal veins during transcranial scanning is an additional indirect sign of intracranial venous stasis, but the use of the method is limited by the absence of an acoustic window [94] according to various data in 10-20% of cases [95][96][97]. The following indirect signs of intracranial venous stasis are obtained with transcranial Doppler: an increase in the maximum blood flow velocity in one or both Rosenthal veins over 25 cm/s, Galen's vein and straight dural sinus > 30 cm/s, the appearance of a pseudopulsation effect, a decrease in the cerebrovascular reactivity index <40%, resistance index increase > 20%.…”
Section: The Native Ct Of the Brain Is Performed Everywhere Immediate...mentioning
The purpose of the narrative review is to search for confirmation or controversy of the hypothesis according to which venous ischemia developing in cerebral venous sinustrombosis is secondary as a result of mechanical narrowing of arterioles in the area of vasogenic edema. This review discusses the issues of multimodal radiological diagnosis of a rare disease of a non-hemorrhagic ischemic venous stroke based on expert opinion, current recommendations and our experience. As a result of the review no contradictions to this hypothesis have been found, and the most characteristic symptoms of CVT, secondary ischemia, intracranial venous congestion can be identified in the order of their probable clinical manifestation from patient complaints to the results of instrumental studies: headache, subacute development and course of the disease, papilledema optic disc, increase of central venous pressure, hypodensity of the ischemic foci and hyperdensity signs of sinus on CT, earlier development of vasogenic edema on diffusion MRI, symptoms of stop-contrast and filling defect thrombosed sinuses on contrast enhancement CTA or MRA, dilatation of venous regional collaterals, moderate hyperperfusion on CT-or MR-perfusion, elevated maximum blood flow velocity Rosenthal veins; Galen's vein and rectus sinus, decreased cerebrovascular reactivity index, increased peripheral resistance index on Transcranial Doppler, clot visualization on brachiocephalic veins ultrasound duplex scanning, decreasing of brachiocephalic vessels ultrasound index of arteriovenous ratio.
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