Durability of the bond between bone and various 2‐cyanoacrylates in an aqueous environment

Abstract

The durability of the bond strength developed between 2-cyanoacrylate esters and bone has been determined by aging specimens in water. One-day bond strength of the isobutyl and isomeric amyl 2-cyanoacrylates varied from 6.2 to 7.2 MPa. The strength of the bond decreased on storage or on thermocycling in water. Hydrolytic stability increased with increasing length of the alkyl ester group. After a six-month storage in water the various amyl 2-cyanoacrylates retained from 70% to 73% of their one-day bond strength. Pretreatment of the bone surface prior to application of the adhesive did not prove beneficial. The cured 2-cyanoacrylate can be removed from the substrate surface by appropriate solvents. Thus, it is not bonded covalently to bone. The bond strength, especially of the isobutyl and amyl 2-cyanoacrylates to bone in an aqueous environment, appears to be superior to other adhesives. Provided these monomers are biocompatible, they may be useful clinically where an intermediate-term adhesion is desired.

Efeito do adesivo butil-2-cianoacrilato em osteotomias e enxerto ósseo em coelhos: aspecto macroscópico e radiográfico

“…These results are also concordant with in vitro observations, which showed that butyl-2-cyanoacrylate presented high initial adhesive resistance (2,14) . It was observed that the radiographic union was best in the proximal osteotomies with adhesive in group C (p = 0.03; Table 5).…”

“…The adhesive butyl-2-cyanoacrylate was chosen because it presents excellent adhesiveness, sterility and elasticity and low toxicity to tissues; does not induce cell neoplasia; has rapid polymerization; is easy to apply to organs of animals of different species; and is eliminated through the normal excretion routes, i.e. urine and feces, and probably also through the respiratory system (9,(14)(15)(16)(17)(18) . Another important factor in choosing butyl-2-cyanoacrylate is that it has already been used in humans, in some European countries and in Canada, without reports of toxic effects (4,19) .…”

Properties and interactions of oral structures and restorative materials

“…The button test results (Table 33) using human dentin as substrate and citric acid pretreatment were in contrast to those of Brauer [63,64] who used bone-bone interface bonding to investigate adhesion with cyanoacryates. acid, the utility of sodium citrate and the di sodium salt of ethylene diamine tetracetic acid (Na 2 EDTA) has been examined.…”

“…However, the results of Brauer et al . [63,64] An objective of the present work was to investigate the bonding of cyanoacrylates to dentin, with particular reference to the bonding mechanism and ways of improving the strength of the bond and its durability.…”

Bone Adhesives in Trauma and Orthopedic Surgery

“…Reports of displacement of the glued fracture ends were followed by reports of high infection rates, non-union, and severe local reactions, with fistula formation, for both 'Cyacrin' adhesion and bone welding [9,14,22].…”