Durability improvement of polymer chamber of pulsatile extracorporeal life support system in terms of mechanical change

Abstract

Twin Pulse Life Support, T-PLS has received the CE mark (2003) and Korea Food and Drug Administration (KFDA) approval (2004) for short-term application as an Extracorporeal Life Support system (ECLS). T-PLS's original intention was to apply for not only short-term but also long-term application such as Extracorporeal ventricular assist device (VAD). Hence, a long-term durability test was conducted. The 1-year reliability of the systems tested in this study did not meet the STS/ASAIO standard of 80% reliability with 60% confidence for a 1-year mission life. However, without the disposable units, which are only designed to operate for 6 h, the 1-year reliability exceeded the STS/ASAIO standard of 80% reliability with 60% confidence. In this study, by using the existing analysis methods and analyzing the root cause of the failure used by a numerical analysis. As eliminating or mitigating of the root cause of the failure, we improved the durability of blood chamber and evaluated the performance of the modified system via the hemolysis test.

A Durability Study of a Paracorporeal Pulsatile Electro‐Mechanical Pneumatic Biventricular Assist Device

“…Some groups have proved their reliable and durable systems (19)(20)(21)(22) and artificial organs such as VAD through durability testing and reliability analysis (23)(24)(25)(26)(27)(28)(29). Our extracorporeal VAD system generates pneumatic pressure with the compression of bellows instead of using an air compressor.…”

Hemodynamic investigation of a novel rotary displacement blood pump for extracorporeal membrane oxygenation

“…The volume of the RDBP is comparable to those of centrifugal pumps and is also portable. The RDBP pumps blood by two rotors rotating independently, eliminates the need for a pump pipeline with silicone or PVC material and thus avoids the risk of pump pipe burst caused by high pipeline pressure 21 . Besides, compared with centrifugal pumps with rotating speeds higher than 3000 rpm, RDBP only needs 60–240 rpm to reach normal operating conditions 22 …”

World Congress on Medical Physics and Biomedical Engineering (WC2006, Seoul)

“…The Congress was a well-appreciated combined initiative of medical physicists and biomedical engineers and we are happy to have four excellent papers highly relevant to diagnosis and treatment of cancer [7,8,11,18]. We have one paper on artificial organs [1] a biomedical engineering development which has been a real success story and saved many lives. Models can deepen our knowledge about behaviour and mechanisms of underlying physiological or biomechanical processes [9,12,19,20].…”