Dupuytren’s disease

Karbowiak, Marta; Holme, T C; Khan, Kamran Ahmed; Mohan, Arvind

doi:10.1136/bmj.n1308

Cited by 7 publications

(8 citation statements)

References 33 publications

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“… The effects of RLX in fibrotic diseases of the ligaments. Image sources of Dupuytren’s disease ( Karbowiak et al, 2021 ) and Scleroderma ( Orteu et al, 2020 ) are from references. …”

Section: Regulation and Mechanism Of Rlx In Fibrotic Ligament Diseasesmentioning

confidence: 99%

“…Pathologically, Dupuytren’s disease is characterized by fibrotic tissue hyperplasia and contracture of the palmar fascia. Finger cramps and dysfunction may occur at the end of the disease ( Badalamente et al, 1983 ; Black and Blazar, 2011 ; Karbowiak et al, 2021 ). Histologically, the initial phase of the disease process was characterized by the thickening of small nodules composed of proliferative cells and fibroblasts ( Shih and Bayat, 2010 ).…”

Section: Regulation and Mechanism Of Rlx In Fibrotic Ligament Diseasesmentioning

confidence: 99%

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Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism

Yuan

Guo

Liang

et al. 2023

Front. Cell Dev. Biol.

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Fibrotic ligament diseases (FLDs) are diseases caused by the pathological accumulation of periarticular fibrotic tissue, leading to functional disability around joint and poor life quality. Relaxin (RLX) has been reported to be involved in the development of fibrotic lung and liver diseases. Previous studies have shown that RLX can block pro-fibrotic process by reducing the excess extracellular matrix (ECM) formation and accelerating collagen degradation in vitro and in vivo. Recent studies have shown that RLX can attenuate connective tissue fibrosis by suppressing TGF-β/Smads signaling pathways to inhibit the activation of myofibroblasts. However, the specific roles and mechanisms of RLX in FLDs remain unclear. Therefore, in this review, we confirmed the protective effect of RLX in FLDs and summarized its mechanism including cells, key cytokines and signaling pathways involved. In this article, we outline the potential therapeutic role of RLX and look forward to the application of RLX in the clinical translation of FLDs.

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“… The effects of RLX in fibrotic diseases of the ligaments. Image sources of Dupuytren’s disease ( Karbowiak et al, 2021 ) and Scleroderma ( Orteu et al, 2020 ) are from references. …”

Section: Regulation and Mechanism Of Rlx In Fibrotic Ligament Diseasesmentioning

confidence: 99%

Section: Regulation and Mechanism Of Rlx In Fibrotic Ligament Diseasesmentioning

confidence: 99%

Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism

Yuan

Guo

Liang

et al. 2023

Front. Cell Dev. Biol.

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“…Но поскольку наш обзор посвящен способам замещения дефектов кожи после апоневрэктомии, то мы будем анализировать только хирургические методики. Среди хирургических способов лечения контрактуры Дюпюитрена выделяют радикальную (тотальную), сегментарную и субтотальную (частичную) апоневрэктомии [7,29].…”

Section: способы лечения контрактуры дюпюитренаunclassified

Skin Closure After Subtotal Aponeurectomy in Severe Dupuytren’s Contracture: Review

Idrisov¹,

Rodomanova

2022

Traumatology and Orthopedics of Russia

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Introduction. One of the significant problems of surgical treatment of Dupuytren's contracture is a deficiency of the skin as a result of suturing the wound after subtotal aponeurectomy. The size of the defect depends on the severity of the pathology. In the early stages of the disease, Z-plasty is widely used, but this method of plastic replacement does not completely cover the defect formed after surgical treatment of contracture of III-IV severity, especially when several fingers of the hand are lesioned. The purpose of the study. The purpose of the review is a comparative analysis of methods of plastic replacement of skin deficiency after subtotal aponeurectomy in patients with III-IV degree of severity of Dupuytren's contracture. Various tactics of treatment of this category of patients are described, including distraction elimination of contracture and further aponeurectomy, as well as various methods of plastic replacement of skin defects formed after resection of altered areas of palmar aponeurosis and elimination of contracture. Each of the proposed methods of surgical treatment has its advantages and disadvantages. Conclusions. An analysis of the relevant scientific literature has shown that the most common method of eliminating soft tissue deficiency after aponeurectomy is Z-plasty. However, due to an increase in the severity of the disease, its effectiveness decreases. To date, there is no consensus regarding the approach to the altered site of aponeurosis and there is no single method for eliminating tissue deficiency in the III-IV degree of the disease.

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“…1 DD affects roughly 8% of the general population in Western populations, where it is most common 2 . Actual prevalence rates differ greatly depending on age group and area 3 .…”

Section: Introductionmentioning

confidence: 99%

“…These may eventually lead to contractures that cause finger flexion abnormalities. The ring and little fingers are most frequently affected, however, the contracture can extend across the metacarpophalangeal and interphalangeal joints 3 15-12-2022 Although various risk factors have been put forth, including smoking, alcohol consumption, hypertension, physical labor, genetic susceptibility and diabetes Mellitus, the exact etiology and pathophysiology of DD are still under controversy. Additionally, many body anthropometrics, such as body mass index, have been explored related to DD, and results showed a decreased risk for DD with a larger BMI 1 .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Dupuytren’s and Sociodemographic Factors Related to it Among Chronic Diabetic Patients

Kalsoom¹,

Iftikhar²,

Islam³

et al. 2023

PJMHS

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Background: Dupuytren’s disease(DD) is characterized by progressive idiopathic fibrosis of the hand palm and the formation of nodules & contractures. Its prevalence ranges from 3 to 42% worldwide. Aim: To assess Dupuytren’s disease’s prevalence, severity and its association with different demographic factors. Study design: Analytical, Cross-sectional study done using Non-probability convenient sampling. Method: This study was conducted on 424 diabetic patients of age between 40 and 80. A questionnaire was used to assess different sociodemographic factors among them. Tubiana classification & tabletop test was used to assess the severity of the disease. Chi-square test was applied to find out the p-value for the association between variables. Results: About 9% of total participants were affected by DD. Most of the affected people were in the nodular stage or stage 1.There was a significant relationship found between DD and different factors like age group (p=<0.01),Family history of DD(p=<0.01), and previous hand injury (p=<0.01) Practical implication: This study provides us the baseline risk factors leading to the disease for better future interventions. Treatments gets easier when we reach the cause. Because nowadays the widely available treatment is surgical excision which is not a good option for everyone. Also there is a dearth of research on this emerging hand disability caused by diabetes that’s why this research is being conducted Conclusions: The results showed high prevalence of DD in diabetic patients with old age, positive family history of DD disease and previous hand injury. Therapeutic studies are required for the betterment of society and to prevent the disease from causing disability. Keywords: Contractures, Dupuytren’s disease, Dupuytren’s nodules, diabetes, personal factors, Family history.

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Dupuytren’s disease

Cited by 7 publications

References 33 publications

Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism

Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism

Skin Closure After Subtotal Aponeurectomy in Severe Dupuytren’s Contracture: Review

Epidemiology of Dupuytren’s and Sociodemographic Factors Related to it Among Chronic Diabetic Patients

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