Dupuytren's Disease and exposure to vibration: Systematic review and Meta-analysis

Mathieu, Sylvain; Naughton, Géraldine; Descatha, Alexis; Soubrier, Martin; Dutheil, Frédéric

doi:10.1016/j.jbspin.2020.02.001

Cited by 15 publications

(15 citation statements)

References 25 publications

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“…Diabetes appears to have long been recognized as a risk factor for the development of DC, although the exact mechanism has not been fully understood [ 11 , 13 ]. The results of a meta-analysis found that the proportion of diabetes in DC patients was significantly higher than that in control [ 14 ]. In addition, studies have found that the incidence of DC in diabetic patients is 10 times that of nondiabetic people, and DC is also considered to be one of the complications of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Zheng

Chen

Liu

et al. 2022

Computational Intelligence and Neuroscience

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Objective. To study the risk factors of Dupuytren’s contracture (DC) and to provide a reference for the clinical prevention and treatment of DC. Methods. The clinical data of 21 DC patients treated with surgery in Qilu Hospital of Shandong University (Qingdao) from March 2014 to January 2022 were collected. During the same period, 31 subjects who were admitted to the hospital for treatment of finger numbness, difficulty in movement, and other reasons were selected as the control group, and the clinical data of the control group were collected. A case-control study was used to analyze the risk factors for DC. The receiver operating curve (ROC) was used to analyze the efficacy of blood biochemical indexes and coagulation-related indexes in predicting the occurrence of DC. Results. Multivariate logistic regression analysis showed that male and diabetes were independent risk factors for the occurrence of DC (HR = 19.69, 95%CI: 3.12–124.19, P = 0.002; HR = 7.61, 95%CI: 1.25–46.47, P = 0.03). The results of the ROC analysis showed that the area under the curve (AUC) for the DC predicted by cystatin C was 0.7565 (95%CI: 0.6203–0.8928, P = 0.0018), and the AUC for the DC predicted by blood chloride level was 0.8121 (95%CI: 0.6880–0.9362, P = 0.0002), the AUC for the DC predicted by fibrinogen was 0.7796 (95%CI: 0.6439–0.9152, P = 0.0007), the AUC for the DC predicted by D-dimer level was 0.8740 (95%CI: 0.7812–0.9669, P < 0.0001), and the AUC for the DC predicted by thrombin time was 0.7803 (95%CI: 0.6411–0.9196, P = 0.0007). The AUC for the DC predicted by the combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time was 0.9441 (95%CI: 0.8926–0.9957, P < 0.001). Conclusion. Male and diabetes are independent risk factors for the occurrence of DC. Combined detection of cystatin C, blood chloride, fibrinogen, D-dimer, and thrombin time has a certain value in predicting the occurrence of DC.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Zheng

Chen

Liu

et al. 2022

Computational Intelligence and Neuroscience

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“…The primary limitation of this study is the number of patients lost to follow-up which raises the possibility of non-responder bias. This study also relied upon self-reporting of HAVexposure and data relating to vibration frequency were unavailable, however this limitation is consistent with previous studies [1,7].…”

Section: Discussionmentioning

confidence: 61%

Hand–arm vibration and outcomes of surgery for Dupuytren’s contracture

Stirling

Jenkins

et al. 2021

Occupational Medicine

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Background Dupuytren’s contracture was recently designated a prescribed occupational disease when it occurs in patients with previous hand–arm vibration (HAV) exposure. Aims The aims of this study were to describe the impact of self-reported HAV exposure on upper limb function and satisfaction following surgery for Dupuytren’s contracture. Methods Paired pre- and postoperative Quick version of Disabilities of the Arm, Shoulder and Hand (QuickDASH) and patient satisfaction questionnaires were prospectively collected from all patients undergoing surgery for Dupuytren’s contracture over a 6-year period. Patients self-reported HAV exposure duration. Results Results were available for 425 hands (65%) at mean 13 months postoperatively. There were 111 patients (26%) that reported HAV exposure. The prevalence of HAV exposure was significantly greater in male compared with female patients (32% versus 4%; P < 0.001). A statistically significant difference in preoperative (difference 7.47; 95% confidence interval 4.78–10.17; P < 0.001) and postoperative QuickDASH score (difference 6.78; 95% confidence interval 2.69–10.88; P < 0.001) was observed between the two groups, but difference in QuickDASH improvement was not significantly different (difference 1.76; 95% confidence interval −1.58 to 5.10; P > 0.05). No significant difference in satisfaction rate or return to work was observed between the two groups. Conclusions Previous HAV exposure influenced the pre and postoperative function in patients undergoing surgery for Dupuytren’s contracture, but had no effect on satisfaction or return to work. Further prospective research will be required to determine whether the introduction of a compensatory framework will have a more profound effect on the functional outcomes of surgery.

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“…It’s Dupuytren’s contracture. You might think of asking him what his occupation is—perhaps he uses vibrating instruments 5. You’ll also ask him questions relating to his drinking habits, thinking about chronic liver disease,6 and ask about symptoms of diabetes mellitus 7.…”

Section: Learning the Medical Tablesmentioning

confidence: 99%

When I use a word . . . . Diagnosis

Aronson

2022

BMJ

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Medical students are taught how to take a patient’s history as one would teach schoolchildren their times tables, by rote. However, in time children become able to calculate simple products without repeating whole tables as they were originally taught. By the same token, although the medical history is taught by rote to begin with, the skilled doctor, with experience, comes to choose and frame questions in ways that most appropriately encourage patients to tell their stories lucidly and to best effect, facilitating the path from story to narrative and from narrative to diagnosis. In skilled hands the patient’s tale and the methods of elucidating it combine effectively. Observation, physical examination, and relevant investigations complete the task of making a complete diagnosis. All parts of the process are required.

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Dupuytren's Disease and exposure to vibration: Systematic review and Meta-analysis

Cited by 15 publications

References 25 publications

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Risk Factors for Dupuytren’s Contracture: A Case-Control Study

Hand–arm vibration and outcomes of surgery for Dupuytren’s contracture

When I use a word . . . . Diagnosis

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