Dupuytren’s Diathesis Revisited: Evaluation of Prognostic Indicators for Risk of Disease Recurrence

Hindocha, Sandip; Stanley, John; Watson, Stewart; Bayat, Ardeshir

doi:10.1016/j.jhsa.2006.09.006

Cited by 153 publications

(126 citation statements)

References 29 publications

(24 reference statements)

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“…The severity of a patient's disease presentation continues to be an important factor in the management of this disease, and recently the statistical risk for disease recurrence based on these diathesis factors has been calculated. 12 In addition to genetic factors, a number of comorbidities and socioenvironmental factors play a role in this condition. Studies have suggested that DD clusters in patients with certain underlying health conditions, such as diabetes mellitus 13,14 and epilepsy.…”

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

Molecular mechanisms and treatment strategies for Dupuytren’s disease

O’Gorman¹,

Vi²,

Gan

2010

TCRM

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Dupuytren's disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment.

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Section: Prevalence and Risk Factorsmentioning

confidence: 99%

Molecular mechanisms and treatment strategies for Dupuytren’s disease

O’Gorman¹,

Vi²,

Gan

2010

TCRM

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“…The presence of bilateral disease and knuckle pads are associated with aggressive course of the disease. Hindocha added two additional factors, male gender and age of onset before 50 years, which were also present (7).…”

Section: Introductionmentioning

confidence: 99%

Dupuytren`s contracture in a patient from Vietnam: A case report

Bozhanina¹,

Popstefanov

2016

SSM

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Dupuytren's disease is a benign fibroproliferative disease of unknown origin, which affects the palmar fascia. The condition usually has a progressive course, from the appearance of a nodule, to the formation of a fibrous cord which pulls the finger in a flexion posture. It is common in Scandinavian countries, frequent in the United Kingdom and is believed to be uncommon in Asian populations. Palmar contracture appears only rarely in Asian people of pure stock (2). Vietnam has evidenced only one case in the literature, from 1971 in a male soldier, with unilateral fourth ray disease, which was treated with subtotal fasciectomy with an unknown outcome (11,14). We report a case of a male patient with bilateral Dupuytren's disease from Vietnam.

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“…Both surgical and non-invasive methods exist for correction of the extension deficit but the treatment does not cure the disease, and the rate of recurrence is high. (2,3) Some surgeons recommend hand therapy after correction of the extension deficit, in order to maintain the gains in finger extension and to restore hand function. (2,4) For patients with DD, the most commonly reported outcome measures are change in extension deficit of the finger joints, and the Disability of the Arm, Shoulder and Hand (DASH) questionnaire.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting functional recovery after surgery and hand therapy in patients with Dupuytren's disease

Engstrand

Krevers

Kvist

2015

Journal of Hand Therapy

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Study designProspective cohort study. IntroductionThe evidence of the relationship between functional recovery and impairment after surgery and hand therapy are inconsistent. Purpose of the studyTo explore factors that were most related to functional recovery as measured by DASH in patients with Dupuytren's disease. MethodsEighty-one patients undergoing surgery and hand therapy were consecutively recruited. ResultsThe three variables "need to take special precautions", "avoid using the hand in social context", and health-related quality of life (EQ-5D index) explained 62.1% of the variance in DASH, where the first variable had the greatest relative effect. DiscussionSafety and social issues of hand function and quality of life had an evident association with functional recovery.

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Dupuytren’s Diathesis Revisited: Evaluation of Prognostic Indicators for Risk of Disease Recurrence

Cited by 153 publications

References 29 publications

Molecular mechanisms and treatment strategies for Dupuytren’s disease

Molecular mechanisms and treatment strategies for Dupuytren’s disease

Dupuytren`s contracture in a patient from Vietnam: A case report

Factors affecting functional recovery after surgery and hand therapy in patients with Dupuytren's disease

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Dupuytren’s Diathesis Revisited: Evaluation of Prognostic Indicators for Risk of Disease Recurrence

Cited by 153 publications

References 29 publications

Molecular mechanisms and treatment strategies for Dupuytren&rsquo;s disease

Molecular mechanisms and treatment strategies for Dupuytren&rsquo;s disease

Dupuytren`s contracture in a patient from Vietnam: A case report

Factors affecting functional recovery after surgery and hand therapy in patients with Dupuytren's disease

Contact Info

Product

Resources

About

Molecular mechanisms and treatment strategies for Dupuytren’s disease

Molecular mechanisms and treatment strategies for Dupuytren’s disease