2013
DOI: 10.11648/j.ass.20130103.11
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Dupuytren Contracture - How Fibromatosis Remodels the Palmar Subcutaneous Tissue and Its Fibrous Environment

Abstract: Our understanding of the process of contracture of the fingers is based on extrinsic and intrinsic theories. Yet there has always been an inherent contradiction in these concepts. Additionally, nearly all of these theories proceed from the assumption of a contractio digitorum and this assumption is reflected in basic research as well. The author presents a concept, which describes the finger contracture more accurately as retention in the flexed position. This contraction-free concept, deduced from the functio… Show more

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Cited by 2 publications
(3 citation statements)
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“…24,25 The mechanism of fibrosis involves de novo transformation from adipose tissue around the palmar aponeurosis, with adipose tissue eventually being replaced with fibrous tissue. 3 Against this pathological background, we hypothesized that adipocytokines secreted from adipose tissue around the palmar aponeurosis may be involved in fibrosis of the palmar aponeurosis in patients with Dupuytren's contracture. In recent years, the adipose tissue has emerged as an endocrine organ that secretes various bioactive substances.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…24,25 The mechanism of fibrosis involves de novo transformation from adipose tissue around the palmar aponeurosis, with adipose tissue eventually being replaced with fibrous tissue. 3 Against this pathological background, we hypothesized that adipocytokines secreted from adipose tissue around the palmar aponeurosis may be involved in fibrosis of the palmar aponeurosis in patients with Dupuytren's contracture. In recent years, the adipose tissue has emerged as an endocrine organ that secretes various bioactive substances.…”
Section: Discussionmentioning
confidence: 99%
“… 1 In contrast, the extrinsic theory holds that nodules arise de novo by transformation of fibrofatty tissue, 2 and eventually, the infiltrating fibrous tissue displaces the adipose tissue. 3 Based on the pathophysiology of fibrosis of the palmar aponeurosis due to de novo fibrotic changes in adipose tissue, adipocytokines secreted from adipose tissue may be involved in the fibrosis of the palmar aponeurosis in Dupuytren’s contracture. Various growth factors and signalling pathways have already been reported to be involved in fibrosis of the palmar aponeurosis in Dupuytren’s contracture.…”
Section: Introductionmentioning
confidence: 99%
“…Контрактура Дюпюитрена (ладонный фасциальный фиброматоз) характеризуется аномально высокой пролиферацией, миграцией и биосинтетической активностью фибробластов и миофибробластов. Узлы и тяжи, сформированные этими клетками, инфильтрируют не только ладонную и пальцевую фасции, но и более поверхностные ткани, в том числе дерму кожи [1], где фибро матоз нередко и начинается [2]. В типичных случаях прогрессирующая контрактура пястно-фаланговых и проксимальных межфаланговых суставов захватывает пальцы локтевой стороны кисти [3].…”
Section: Introductionunclassified