Duplication of 2q41-qter as a sole aberration in a case of non-Hodgkin's lymphoma

Bajalica‐Lagercrantz, Svetlana; Pedersen, Niels Tinggaard; Sørensen, Anne‐Grethe ‐G; Nordenskjöld, Magnus

doi:10.1016/s0165-4608(96)00092-1

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…JPO1 localizes to chromosome 2q31 by fluorescent in situ hybridization, and there are several citations in the literature of chromosomal abnormalities at 2q31. These abnormalities were reported in two cases of nonHodgkin's lymphoma (52,53), one case of chronic myeloid leukemia (54), and one case of adult T cell leukemia (55). Whether these translocations affect JPO1 expression remains to be established.…”

Section: Figmentioning

confidence: 99%

“…c-Myc heterodimerizes with a partner protein, Max, through the C-terminal helix-loop-helix Zip domain (12,13), and together Myc and Max bind DNA specifically (14,15) to activate transcription through the core sequence 5Ј-CA(C/T)GTG-3Ј, also known as an E box (16,17). The N-terminal transactivation domain of c-Myc contains two highly conserved regions among the Myc family of proteins; these regions are termed Myc Box I (c-Myc residues [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] and Myc Box II (c-Myc residues 128 -143) (16). Despite the wealth of knowledge that has accumulated about c-Myc, the connection between elevated c-Myc levels and oncogenesis remains incompletely understood (18,19).…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Novel c-Myc- responsive Gene, JPO1, Participates in Neoplastic Transformation

Prescott¹,

Osthus²,

Lee³

et al. 2001

Journal of Biological Chemistry

View full text Add to dashboard Cite

We have identified a novel c-Myc-responsive gene, named JPO1, by representational difference analysis. JPO1 responds to two inducible c-Myc systems and behaves as a direct c-Myc target gene. JPO1 mRNA expression is readily detectable in the thymus, small intestine, and colon, whereas expression is relatively low in spleen, bone marrow, and peripheral leukocytes. We cloned a full-length JPO1 cDNA that encodes a 47-kDa nuclear protein.

show abstract

Section: Figmentioning

confidence: 99%

mentioning

confidence: 99%

A Novel c-Myc- responsive Gene, JPO1, Participates in Neoplastic Transformation

Prescott¹,

Osthus²,

Lee³

et al. 2001

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

Primary mediastinal (thymic) large B-cell lymphoma with a der(14)t(8;14)(q24;q32) and a translocation of MYC to the derivative chromosome 14 with a deleted IgH locus

Stejskalová

Jarošová

Kabíčková

et al. 2006

Cancer Genetics and Cytogenetics

View full text Add to dashboard Cite

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

Thomas¹,

Olson²,

Tapscott³

et al. 2001

Genome Res.

286

192

View full text Add to dashboard Cite

We have developed a statistical regression modeling approach to discover genes that are differentially expressed between two predefined sample groups in DNA microarray experiments. Our model is based on well-defined assumptions, uses rigorous and well-characterized statistical measures, and accounts for the heterogeneity and genomic complexity of the data. In contrast to cluster analysis, which attempts to define groups of genes and/or samples that share common overall expression profiles, our modeling approach uses known sample group membership to focus on expression profiles of individual genes in a sensitive and robust manner. Further, this approach can be used to test statistical hypotheses about gene expression. To demonstrate this methodology, we compared the expression profiles of 11 acute myeloid leukemia (AML) and 27 acute lymphoblastic leukemia (ALL) samples from a previous study ) and found 141 genes differentially expressed between AML and ALL with a 1% significance at the genomic level. Using this modeling approach to compare different sample groups within the AML samples, we identified a group of genes whose expression profiles correlated with that of thrombopoietin and found that genes whose expression associated with AML treatment outcome lie in recurrent chromosomal locations. Our results are compared with those obtained using t-tests or Wilcoxon rank sum statistics.

show abstract

Duplication of 2q41-qter as a sole aberration in a case of non-Hodgkin's lymphoma

Cited by 3 publications

References 15 publications

A Novel c-Myc- responsive Gene, JPO1, Participates in Neoplastic Transformation

A Novel c-Myc- responsive Gene, JPO1, Participates in Neoplastic Transformation

Primary mediastinal (thymic) large B-cell lymphoma with a der(14)t(8;14)(q24;q32) and a translocation of MYC to the derivative chromosome 14 with a deleted IgH locus

An Efficient and Robust Statistical Modeling Approach to Discover Differentially Expressed Genes Using Genomic Expression Profiles

Contact Info

Product

Resources

About