Duplication and Divergence of Zebrafish CRALBP Genes Uncovers Novel Role for RPE- and Müller-CRALBP in Cone Vision

Collery, Ross F; McLoughlin, Sarah; Vendrell, Victor; Finnegan, Jennifer M.; Crabb, John W.; Saari, John C.; Kennedy, Breandán N.

doi:10.1167/iovs.08-1957

Cited by 47 publications

(53 citation statements)

References 48 publications

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“…Collery et al additionally used an antibody against cone blue-opsin to test for cone integrity after Cralbp b knock-down. In concordance with our results, they did not detect any abnormalities in cone morphology or opsin expression (Collery et al, 2008;Fleisch et al, 2008). Our data in zebrafish mirror the data published in the Cralbp knock-out mouse model.…”

Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fsupporting

confidence: 93%

“…Collery et al reported that knock-down of both zebrafish Cralbp proteins resulted in a significant reduction in the number of saccades in the OKR (Collery et al, 2008). In contrast to that, we found that visual performance, measured as a contrast sensitivity function, was significantly impaired in zebrafish larvae injected with the Müller cell-specific cralbp b MO, but cralbp a MO-injected fish did not differ from wildtype controls (Fleisch et al, 2008) (Figure 5).…”

Section: Cone Photoreceptors Use Both the Canonical And The Intra-recontrasting

confidence: 73%

“…Notably, these two paralogs are expressed in the two compartments believed to be involved in chromophore regeneration -cralbp a in the zebrafish RPE, and cralbp b in Müller glia cells, in both the larval and adult retina (Collery et al, 2008;Fleisch et al, 2008). This specific expression pattern suggests a sub-functionalization of the two cralbp genes which had arisen during teleost evolution and allowed us to separately assess the role of each paralog in retinoid recycling in the zebrafish ( Fleisch et al, 2008).…”

Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fmentioning

confidence: 99%

“…Whereas rodents (and humans) possess only one gene encoding CRALBP, zebrafish possess two variants of the mammalian CRALBP gene -cralbp a and cralbp b (Collery et al, 2008;Fleisch et al, 2008). Notably, these two paralogs are expressed in the two compartments believed to be involved in chromophore regeneration -cralbp a in the zebrafish RPE, and cralbp b in Müller glia cells, in both the larval and adult retina (Collery et al, 2008;Fleisch et al, 2008).…”

Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fmentioning

confidence: 99%

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Parallel visual cycles in the zebrafish retina

Fleisch

2010

Progress in Retinal and Eye Research

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Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.

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Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fsupporting

confidence: 93%

Section: Cone Photoreceptors Use Both the Canonical And The Intra-recontrasting

confidence: 73%

Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fmentioning

confidence: 99%

Section: Subfunctionalization Of Zebrafish Cralbp Provides Evidence Fmentioning

confidence: 99%

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Parallel visual cycles in the zebrafish retina

Fleisch

2010

Progress in Retinal and Eye Research

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“…However, cone vision of RPE65-knockdown larvae remained functional as demonstrated by behavioural tests and by metabolite profiling for retinoids (Schonthaler et al 2007). The zebrafish genome also contains two CRALBP orthologues: rlbp1a and rlbp1b (Collery et al 2008;Fleisch et al 2008). CRALBP-a is exclusively expressed in the RPE, whereas CRALBP-b is localized to Mü ller cells.…”

Section: Diversity Of the Visual Retinoid Cycle In Vertebrates (A) Romentioning

confidence: 99%

Evolution and the origin of the visual retinoid cycle in vertebrates

Kusakabe

Takimoto

Jin

et al. 2009

Phil. Trans. R. Soc. B

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Absorption of a photon by visual pigments induces isomerization of 11-cis-retinaldehyde (RAL) chromophore to all-trans-RAL. Since the opsins lacking 11-cis-RAL lose light sensitivity, sustained vision requires continuous regeneration of 11-cis-RAL via the process called 'visual cycle'. Protostomes and vertebrates use essentially different machinery of visual pigment regeneration, and the origin and early evolution of the vertebrate visual cycle is an unsolved mystery. Here we compare visual retinoid cycles between different photoreceptors of vertebrates, including rods, cones and non-visual photoreceptors, as well as between vertebrates and invertebrates. The visual cycle systems in ascidians, the closest living relatives of vertebrates, show an intermediate state between vertebrates and non-chordate invertebrates. The ascidian larva may use retinochrome-like opsin as the major isomerase. The entire process of the visual cycle can occur inside the photoreceptor cells with distinct subcellular compartmentalization, although the visual cycle components are also present in surrounding non-photoreceptor cells. The adult ascidian probably uses RPE65 isomerase, and trans-to-cis isomerization may occur in distinct cellular compartments, which is similar to the vertebrate situation. The complete transition to the sophisticated retinoid cycle of vertebrates may have required acquisition of new genes, such as interphotoreceptor retinoid-binding protein, and functional evolution of the visual cycle genes.

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Central Retinal Findings in Bothnia Dystrophy Caused by RLBP1 Sequence Variation

Burstedt

Golovleva²

2010

Arch Ophthalmol

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To describe the central retinal findings early in the course of Bothnia dystrophy caused by the homozygous missense R234W sequence variation in the RLBP1 gene. Methods: In 8 young patients with Bothnia dystrophy (aged 9-34 years), high-and low-contrast distance visual acuity and visual fields were measured with Humphrey central (24-2) threshold testing and Goldmann perimetry. Central retinal thickness was measured with optical coherence tomography. Cross-sectional images were analyzed and a linear scanning protocol was applied to examine retinitis punctata albescence in the posterior pole. Results: Affected visual acuity (4 of 8 cases) and poor low-contrast visual acuity (8 of 8 cases) were found. Significant foveal depression and visual field loss were evident with Humphrey threshold testing at all ages, and paracentral and central scotomata in the second decade of life advanced in adulthood as verified with Gold

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Duplication and Divergence of Zebrafish CRALBP Genes Uncovers Novel Role for RPE- and Müller-CRALBP in Cone Vision

Abstract: The results suggest that cone photoreceptors incorporate 11-cis-retinoids derived from the rod and cone visual cycles into their visual pigments and that Müller-CRALBP participates in the cone visual cycle.

Cited by 47 publications

References 48 publications

Parallel visual cycles in the zebrafish retina

Parallel visual cycles in the zebrafish retina

Evolution and the origin of the visual retinoid cycle in vertebrates

Central Retinal Findings in Bothnia Dystrophy Caused by RLBP1 Sequence Variation

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