Duplex-specific nuclease powered 3D DNA walker and quantum dots barcodes for homogeneous electrochemical detection of microRNAs

Fe Single-Atom Carbon Dots Nanozyme Collaborated with Nucleic Acid Exonuclease III-Driven DNA Walker Cascade Amplification Strategy for Circulating Tumor DNA Detection

“…Furthermore, the straightforward analysis of ctDNA would be difficult and could be reasonably converted to other biological signals . In terms of flexibility, affordability, simplicity of operation, and potential applications in even detection, electrochemical biosensors have received much attention in recent years. , Presently, the buildup of electrochemical biosensing platforms in which nanomaterials and isothermal amplification strategies are used has great advantages in improving the sensitivity and accuracy of detectors. , Nanozymes are classified as quantum nanomaterials that catalog the enzymatic substrate chemical reaction by following enzyme kinetics under physiological conditions . In a few years, single-atom nanozymes have been emerging as a flashpoint for research due to their abundant and atomically dispersed individual active metal atoms, which can show excellent natural enzyme activity.…”