Duplex scan and histologic assessment of acute renal injury in a kidney-kidney crosstalk swine experimental model

Sincos, Anna Paula Weinhardt Baptista; Mazzeo, Angela; Sincos, Igor Rafael; Neto, Felipe Coelho; Wolosker, Nelson; Aun, Ricardo; Leite, Kátia R. M.; Paula, Vitória Penido de; Kaufmann, Oskar Grau

doi:10.1016/j.jvs.2017.06.118

Cited by 4 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to our study, the presence of lesion in control kidneys in both groups may be justified by crosstalk phenomenon (21). Crosstalk is observed when there is a lesion from a ischemia-perfusion event, that may diffuse to other organs such as lungs, liver and heart.…”

Section: Discussionmentioning

confidence: 53%

Study of kidney morphologic and structural changes related to different ischemia times and types of clamping of the renal vascular pedicle

et al. 2019

Self Cite

View full text Add to dashboard Cite

Purpose This study aimed to study morphological and renal structural changes in relation to different ischemic times and types of renal vascular pedicle clamping.Methods Sixteen pigs were divided into two groups (n = 8): Group AV - unilateral clamping of the renal artery and vein and Group A - unilateral clamping of the renal artery only, both with the contralateral kidney used as control. Serial biopsies were performed at 0, 10, 20, 30, 40, 50, 60, 70, 80, and 90 minutes after clamping.Results there is a correlation between the occurrence of renal damage as a function of time (p <0.001), with a higher frequency of Group A lesions for cellular alterations (vascular congestion and edema, interstitial inflammatory infiltrate, interstitial hemorrhage and cell degeneration), with the exception of in the formation of pigmented cylinders that were evidenced only in the AV Group.Conclusion the number of lesions derived from ischemia is associated with the duration of the insult, there is a significant difference between the types of clamping, and the AV Group presented a lower frequency of injuries than Group A. The safety time found for Group A was 10 minutes and for Group AV 20 minutes.

show abstract

Section: Discussionmentioning

confidence: 53%

Study of kidney morphologic and structural changes related to different ischemia times and types of clamping of the renal vascular pedicle

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Follow-up was limited due to the proportionately restricted structure of our Center for Experimentation and Training in Surgery, in which keeping the animals longer could compromise their wellbeing due to their growth. In previous studies conducted by our group, we observed that at 4 weeks, animals had developed sufficiently for outcomes to be observed without jeopardizing animal handling due to their size or weight (24)(25)(26).…”

Section: ' Discussionmentioning

confidence: 76%

“…In this study, we developed an experimental porcine model to study the hemodynamic effects of MFMSs in artificially implanted saccular aneurysms in the aorta. Swine is used because it is an excellent biomedical model that closely replicates anatomical, physiological, and immunological conditions in humans (24)(25)(26)(27).…”

Section: ' Discussionmentioning

confidence: 99%

Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model

Strazzi

Aun

Sincos

et al. 2021

Clinics

Self Cite

View full text Add to dashboard Cite

We sought to analyze the hemodynamic effects of the multilayer flow-modulated stent (MFMS) in Thoracoabdominal aortic aneurysms (TAAAs). METHODS: The hemodynamic effects of MFMS were analyzed in aortic thoracoabdominal aneurysms in experimental swine models. We randomly assigned 18 pigs to the stent or control groups and underwent the creation of an artificial bovine pericardium transrenal aneurysm. In the stent group, an MFMS (Cardiatis, Isnes, Belgium) was immediately implanted. After 4 weeks, we evaluated aneurysm sac thrombosis and renal branch patency by angiography, duplex scan, and morphological analysis. RESULTS: All the renal arteries remained patent after re-evaluation in both groups. Aneurysmal sac thrombosis was absent in the control group, whereas in the stent group it was present in 66.7% of aneurysmal sacs (p=0.061). The mean final aneurysm sac diameter was significantly lower in the stent group (mean estimated reduction, 6.90 mm; p=0.021). The proximal neck diameter decreased significantly in the stent group (mean difference, 2.51 mm; p=0.022) and grew significantly in the control group (mean difference, 3.02 mm; p=0.007). The distal neck diameter increased significantly in the control group (mean difference, 3.24 mm; p=0.017). There were no significant findings regarding distal neck measurements in the stent group. CONCLUSION: The MFMSs remained patent and did not obstruct the renal arteries within 4 weeks. In the stent group, the device was also associated with a significant decrease in aneurysmal sac diameter and a large proportion (albeit non-significant) of aneurysmal sac thrombosis.

show abstract

“…Yorkshire pigs were used in the improvement of techniques, such as robot-assisted anatrophic nephrolithotomy, reducing the morbidity during this procedure 22 . Animals of the same breed, with an average weight of 35 kg, were used to evaluate the efficiency of a new retroperitoneal dialysis technique 23 and animals between 3 and 4 months (weighting between 29 and 35 kg) were used in experiments of ischemia and renal reperfusion 24 . The anatomy of the renal arteries, including their angles and branching patterns, was described by angiography in Landrace and Yorkshire pigs weighing between 50 and70 kg 25 .…”

Section: Discussionmentioning

confidence: 99%

Image-guided study of swine anatomy as a tool for urologic surgery research and training

et al. 2020

View full text Add to dashboard Cite

show abstract

Duplex scan and histologic assessment of acute renal injury in a kidney-kidney crosstalk swine experimental model

Abstract: Nonischemic kidneys were acutely affected by contralateral ischemia. Their function was more adversely affected by unilateral renal artery occlusion with preserved renal vein patency (A group).

Cited by 4 publications

References 24 publications

Study of kidney morphologic and structural changes related to different ischemia times and types of clamping of the renal vascular pedicle

Study of kidney morphologic and structural changes related to different ischemia times and types of clamping of the renal vascular pedicle

Multilayer stents affect the final diameter of aortic aneurysms and maintain renal artery patency for a short time in a swine experimental model

Image-guided study of swine anatomy as a tool for urologic surgery research and training

Contact Info

Product

Resources

About