Duodenaltumoren

Instability of Digoxin in Acid Medium Using a Nonisotopic Method

“…The acid hydrolysis of digitalis glycosides was the subject of many studies. As early as 1897, it was observed that a decrease in the efficacy of the glycosides occurred after prior incubation with acidic gastric juices (1,2). Later studies confirmed the in vitro hydrolysis of the glycosides in acid media, as determined by TLC separation followed by colorimetric estimation or by an isotopic technique (3-5).…”