Duodenal ulcer disease in children

Abstract

Eleven cases of chronic duodenal ulcer in children were subjected to surgical treatment in a period of 7 years. The diagnosis was based on typical peptic ulcer symptoms, hyperchlorhydria, and barium meal x-ray studies delineating a duodenal bulb deformity with an ulcer crater in 8 patients. Three cases of duodenal ulcer perforation in infants were diagnosed at aparotomy for peritonitis with pneumoperitoneum. All the patients hailed from the rgion of Assam, India, where peptic ulcer is prevalent. A positive family history of peptic ulcer in 5 patients, blood group O in 7 patients, and the regional diet were considered to be predisposing factors. Medical treatment consisting of a bland diet, sedatives, antispasmodics, and a brief hospital stay failed to provide permanent relief of symptoms. Truncal vagotomy with a drainage procedure was done in 8 patients with no deaths. However, simple closure of the perforation in the 3 infants resulted in fatalities due to fulminant septicemia. The patients were followed up for 1-8 years. Six patients had permanent relief of symptoms. Two patients occasionally complained of epigastric fullness and eructation. They showed normal growth, gain in weight and hemoglobin levels, and had no recurrence. We believe that operative treatment is preferable to medical management of chronic duodenal ulcer in children.

Duodenal Ulcer Perforation in Pediatric Population: A Rare Entity

“…Exact etiology and pathology is not known but it have been reported that the incidence is 1.55 cases per year in the Indian population. 5 Risk factors for duodenal perforation in children are as like the adults. Duodenal ulcer in children can also be associated with Zollinger Ellison syndrome, sickle cell anemia, Helicobacter pylori infection and blood group "O" but in western countries it is due to the steroid administration, NSAIDS and in the Asian countries, it is due to the malaria, gastroenteritis or lymphoma.…”

Perforated duodenal ulcer: A rare complication of deferasirox in children

“…[1] Because of its rarity, its diagnosis is usually over-looked unless it presents with complications. The usual manifestations of a complicated duodenal ulcer are perforation and hemorrhage.…”