Duodenal involvement in Schistosoma mansoni infection.

Contractor, Qais; Benson, Linda M.; Schulz, Tom; Contractor, Tanupriya; Kasturi, Nirupama

doi:10.1136/gut.29.7.1011

Cited by 14 publications

(9 citation statements)

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“…Eggs were purified from digested sections of liver or ileum of infected animals as previously described. 42 Quantitative real-time RT-PCR Total murine RNA was reverse transcribed by Transcriptor First Strand cDNA Synthesis Kit (Roche) according to manufacturer's instructions. Real-time PCR was performed with LightCycler® 480 SYBR Green I Master mix in LightCycler® 480 II (Roche).…”

Section: Discussionmentioning

confidence: 99%

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

et al. 2019

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Basic leucine zipper transcription factor 2 (Batf2) activation is detrimental in Type 1-controlled infectious diseases, demonstrated during infection with Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes Lm. In Batf2-deficient mice (Batf2 −/−), infected with Mtb or Lm, mice survived and displayed reduced tissue pathology compared to infected control mice. Indeed, pulmonary inflammatory macrophage recruitment, pro-inflammatory cytokines and immune effectors were also decreased during tuberculosis. This explains that batf2 mRNA predictive early biomarker found in active TB patients is increased in peripheral blood. Similarly, Lm infection in human macrophages and mouse spleen and liver also increased Batf2 expression. In striking contrast, Type 2-controlled schistosomiasis exacerbates during infected Batf2 −/− mice with increased intestinal fibro-granulomatous inflammation, pro-fibrotic immune cells, and elevated cytokine production leading to wasting disease and early death. Together, these data strongly indicate that Batf2 differentially regulates Type 1 and Type 2 immunity in infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

et al. 2019

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“…In our case, no parasites or eggs were detected in the biopsies of the mucosa suggesting a low worm burden. Intestinal involvement in S. mansoni infection is usually confined to the ileum and colon, but duodenal involvement has also been reported [ 24 ]. In the early stage of the disease, the colonoscopy can range from normal mucosa to edematous, congestive mucosa, petechial hemorrhage or even frank ulcerations.…”

Section: Discussionmentioning

confidence: 99%

Schistosomiasis manifesting as a colon polyp: a case report

Issa

Osman

Aftimos³

2014

J Med Case Reports

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IntroductionSchistosomiasis is a rare disease with a common intestinal involvement. However, colon polyps associated with Schistosoma in the absence of inflammation have rarely been reported, especially in young people; this is the first case with the following presentation.Case presentationWe describe the case of a 20-year-old Ethiopian woman living in Lebanon who presented with nonspecific abdominal symptoms. Her biochemical profile was normal in addition to the results of her stool and urine tests. A colonoscopy showed normal colonic mucosa but surprisingly a large pedunculated polyp was found in her ascending colon. Pathology revealed a hamartomatous polyp but it was full of partially calcified parasitic eggs of Schistosoma mansoni compatible with chronic schistosomiasis.ConclusionsShe was treated with two doses of praziquantel and showed immediate marked clinical improvement. This unusual case will give us the opportunity to discuss schistosomiasis, its occurrence in colon polyps, clinical significance and the various means of management.

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“…Fibrotic strictures [57], fistulas [58,59], bowel perforation [60][61][62], and other consequences of chronic bowel inflammation in schistosomiasis have been reported [63,64] but are less common than polyposis. These disease manifestations usually require surgical treatment, obviously in concert with antischistosomal chemotherapy.…”

Section: Intestinal Schistosomiasismentioning

confidence: 99%

Gastrointestinal complications of schistosomiasis

Schafer

Hale²

2001

Curr Gastroenterol Rep

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Schistosomiasis is an important disease in many parts of the world and has affected the course of human history many times over. The parasitic infection is acquired during contact with infected water. A chronic inflammatory response to schistosome eggs, mediated by both cellular and humoral mechanisms, is the root of the pathology seen in schistosomiasis. Hepatosplenic disease results in intrahepatic presinusoidal portal hypertension. The resultant esophageal and gastric varices are an important cause of morbidity and mortality. Standard treatment guidelines for managing varices can be applied to patients with schistosomiasis. Coinfection with viral hepatitis results in liver disease that progresses more rapidly and is more difficult to treat. Intestinal schistosomiasis may be confused with other disease states and can be an important cause of morbidity, especially in heavily infected patients. Diagnosis relies on demonstration of schistosome eggs in feces or tissue. Praziquantel is the treatment of choice. The development of a vaccine for schistosomiasis is an important goal in the attempt to control this disease.

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Duodenal involvement in Schistosoma mansoni infection.

Cited by 14 publications

References 1 publication

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

Schistosomiasis manifesting as a colon polyp: a case report

Gastrointestinal complications of schistosomiasis

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