Duodenal Involvement by Breast Cancer

Campanile, Francesco; Maurea, Simone; Mainenti, Pier Paolo; Corvino, Antonio; Imbriaco, Massimo

doi:10.1111/tbj.12034

Cited by 10 publications

(5 citation statements)

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“…Patients presenting with chronic vomiting with or without failure to thrive and intolerance of age-appropriate per oral intake need to be assessed with conscious awareness of possible yet undiagnosed ICDO. This is equally attributable both to undiagnosed congenital lesions and the wide spectrum of acquired lesions of the adults` duodenum[19,20,21].…”

Section: Discussionmentioning

confidence: 99%

Comparison of outcomes between complete and incomplete congenital duodenal obstruction

Gfroerer¹,

Theilen²,

Fiegel³

et al. 2019

WJG

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BACKGROUND Congenital duodenal obstruction (CDO) can be complete (CCDO) or incomplete (ICDO). To date there is no outcome analysis available that compares both subtypes. AIM To quantify and compare the association between CCDO and ICDO with outcome parameters. METHODS We retrospectively reviewed all patients who underwent operative repair of CCDO or ICDO in our tertiary care institution between January 2004 and January 2017. The demographics, clinical presentation, preoperative diagnostics and postoperative outcomes of 50 patients were compared between CCDO ( n = 27; atresia type 1-3, annular pancreas) and ICDO ( n = 23; annular pancreas, web, Ladd´s bands). RESULTS In total, 50 patients who underwent CDO repair were enrolled and followed for a median of 5.2 and 3.9 years (CCDO and ICDO, resp.). CCDO was associated with a significantly higher prenatal ultrasonographic detection rate (88% versus 4%; CCDO vs ICDO, P < 0.01), lower gestational age at birth, lower age and weight at operation, higher rate of associated congenital heart disease (CHD), more extensive preoperative radiologic diagnostics, higher morbidity according to Clavien-Dindo classification and comprehensive complication index (all P ≤ 0.01). The subgroup analysis of patients without CHD and prematurity showed a longer time from operation to the initiation of enteral feeds in the CCDO group ( P < 0.01). CONCLUSION CCDO and ICDO differ with regard to prenatal detection rate, gestational age, age and weight at operation, rate of associated CHD, preoperative diagnostics and morbidity. The degree of CDO in mature patients without CHD influences the postoperative initiation of enteral feeding.

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Section: Discussionmentioning

confidence: 99%

Comparison of outcomes between complete and incomplete congenital duodenal obstruction

Gfroerer¹,

Theilen²,

Fiegel³

et al. 2019

WJG

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“…Most lesions are identified during surveillance imaging or incidentally in patients having routine or urgent scans for other reasons. There were also reports of metastatic involvement in other gastroenteric tracts like duodenal metastasis by breast cancer[ 15 ] and renal cell carcinoma[ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical treatments of recurrent small intestine metastatic melanoma manifesting with gastrointestinal hemorrhage and intussusception: A case report

Fan¹,

Cheng²

2023

World J Gastrointest Oncol

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BACKGROUND Melanoma is the most aggressive form of skin cancer, with a tendency to metastasize to any organ. Malignant melanoma is the most frequent cause of skin cancer-related deaths worldwide. Small intestine cancers especially small intestine metastases are relatively rare. Small intestine metastases are seldom described and likely underdiagnosed. Intussusception is most common in pediatric age, and in adults are almost 5% of all cases. CASE SUMMARY A 75-year-old man with a history of acral malignant melanoma was admitted to the Gastroenterology Department of our hospital, complaining of intermittent melena for 1 mo. Magnetic resonance enterography showed partial thickening of the jejunal wall and formation of a soft tissue mass, indicating a neoplastic lesion with jejunojejunal intussusception. The patient underwent partial small bowel resection. Pathological findings and immunohistochemical staining indicated small intestine metastatic melanoma. The patient refused further anti-tumor treatment after the surgery. Ten months after the first surgery, the patient presented with melena again. Computed tomography enterography showed the anastomotic stoma was normal without thickening of the intestinal wall, and routine conservative treatment was given. Three months later, the patient developed melena again. The patient underwent a second surgery, and multiple metastatic melanoma lesions were found. The patient refused adjuvant anti-tumor treatment and was alive at the latest follow-up. CONCLUSION Small intestine metastatic melanoma should be suspected in any patient with a history of malignant melanoma and gastrointestinal symptoms.

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“…It has also been discovered that approximately one in five patients with ESCC who survive > 6 mo in Western societies develop a second primary cancer within 15 years[ 8 ]. Notably, due to the rarity of small bowel tumors and their nonspecific symptoms[ 9 ], primary DA and associated MPMNs are rarely reported. Even fewer studies that examine the genomics and immunomics of MPMNs in depth have been published.…”

Section: Discussionmentioning

confidence: 99%

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

Huang,

Ying,

Chen

et al. 2023

World J Gastrointest Surg

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BACKGROUND The prevalence of multiple primary malignant neoplasms (MPMNs) is increasing in parallel with the incidence of malignancies, the continual improvement of diagnostic models, and the extended life of patients with tumors, especially those of the digestive system. However, the co-existence of MPMNs and duodenal adenocarcinoma (DA) is rarely reported. In addition, there is a lack of comprehensive analysis of MPMNs regarding multi-omics and the tumor microenvironment (TME). CASE SUMMARY In this article, we report the case of a 56-year-old man who presented with a complaint of chest discomfort and abdominal distension. The patient was diagnosed with metachronous esophageal squamous cell carcinoma and DA in the Department of Oncology. He underwent radical resection and chemotherapy for the esophageal tumor, as well as chemotherapy combined with a programmed death-1 inhibitor for the duodenal tumor. The overall survival was 16.6 mo. Extensive evaluation of the multi-omics and microenvironment features of primary and metastatic tumors was conducted to: (1) Identify the reasons responsible for the poor prognosis and treatment resistance in this case; and (2) Offer novel diagnostic and therapeutic approaches for MPMNs. This case demonstrated that the development of a second malignancy may be independent of the location of the first tumor. Thus, tumor recurrence (including metastases) should be distinguished from the second primary for an accurate diagnosis of MPMNs. CONCLUSION Multi-omics characteristics and the TME may facilitate treatment selection, improve efficacy, and assist in the prediction of prognosis.

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Duodenal Involvement by Breast Cancer

Cited by 10 publications

References 0 publications

Comparison of outcomes between complete and incomplete congenital duodenal obstruction

Comparison of outcomes between complete and incomplete congenital duodenal obstruction

Surgical treatments of recurrent small intestine metastatic melanoma manifesting with gastrointestinal hemorrhage and intussusception: A case report

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

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