Duodenal hypertension in practice of gastroenterologist

Губергриц, Н. Б.; Belyaeva, N.V.; Лукашевич, Г. М.; Фоменко, П. Г.; Borodiy, K. N.; Linevskaya, K. Y.

doi:10.30978/mg-2020-3-7

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“…It occurs when the lumen of the duodenum is connected to the lumen of the bile duct, resulting in the disruption or even loss of the barrier function of the sphincter of Oddi[ 16 ]. The basal pressure, which is normally created by the sphincter of Oddi (135-202 mm H 2 O), is higher than that in the duodenum (80-120 mm H 2 O)[ 31 , 32 ]. Phase contractions of the duodenum are accompanied by an increase in pressure and simultaneous initiation of the sphincter of Oddi contractions, which, in turn, prevent reflux[ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a new approach to minimally invasive surgery in palliative treatment of patients with distal malignant biliary obstruction

Susak¹,

Markulan²,

Lobanov³

et al. 2023

World J Gastrointest Surg

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BACKGROUND Palliative endoscopic biliary drainage is the primary treatment option for the management of patients with jaundice which results from distal malignant biliary obstruction (DMBO). In this group of patients, decompression of the bile duct (BD) allows for pain reduction, symptom relief, chemotherapy administration, improved quality of life, and increased survival rate. To reduce the unfavorable effects of BD decompression, minimally invasive surgical techniques require continuous improvement. AIM To develop a technique for internal-external biliary-jejunal drainage (IEBJD) and assess its effectiveness in comparison to other minimally invasive procedures in the palliative treatment of patients with DMBO. METHODS A retrospective analysis of prospectively collected data was performed, which included 134 patients with DMBO who underwent palliative BD decompression. Biliary-jejunal drainage was developed to divert bile from the BD directly into the initial loops of the small intestine to prevent duodeno-biliary reflux. IEBJD was carried out using percutaneous transhepatic access. Percutaneous transhepatic biliary drainage (PTBD), endoscopic retrograde biliary stenting (ERBS), and internal-external transpapillary biliary drainage (IETBD) were used for the treatment of study patients. Endpoints of the study were the clinical success of the procedure, the frequency and nature of complications, and the cumulative survival rate. RESULTS There were no significant differences in the frequency of minor complications between the study groups. Significant complications occurred in 5 (17.2%) patients in the IEBJD group, in 16 (64.0%) in the ERBS group, in 9 (47.4%) in the IETBD group, and in 12 (17.4%) in the PTBD group. Cholangitis was the most common severe complication. In the IEBJD group, the course of cholangitis was characterized by a delayed onset and shorter duration as compared to other study groups. The cumulative survival rate of patients who underwent IEBJD was 2.6 times higher in comparison to those of the PTBD and IETBD groups and 20% higher in comparison to that of the ERBS group. CONCLUSION IEBJD has advantages over other minimally invasive BD decompression techniques and can be recommended for the palliative treatment of patients with DMBO.

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