Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

Sato, Yasuharu; Ichimura, Kouichi; Tanaka, Takehiro; Takata, Katsuyoshi; Morito, Toshiaki; Sato, Hiaki; Kondo, Eisaku; Yanai, Hiroyuki; Ohara, Nobuya; Oka, Takashi; Yoshino, Tadashi

doi:10.1136/jcp.2007.049825

Cited by 67 publications

(70 citation statements)

References 34 publications

(25 reference statements)

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“…1,2 On the other hand, we have also reported that duodenal FLs harbor t(14;18)(IGH-BCL-2), exhibit ongoing somatic hypermutations, and express CD10 and B-cell lymphoma 2 (BCL-2), which are common features of nodal FL. However, the proteins have roles in somatic hypermutation in duodenal FL have not yet been identified.…”

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confidence: 99%

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

et al. 2013

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We have reported previously that duodenal follicular lymphoma (FL) is distinct from nodal FL and showed more resemblance to mucosa-associated lymphoid tissue lymphoma, and that FL frequently involved the duodenal second portion. In the present study, we examined duodenal FLs and gastric/colonic FLs to clarify the clinicopathological and immunological differences between the tumor types. We analyzed 8 samples of gastric FL, 17 of duodenal ones, and 5 of colonic/rectal ones, and characterized them by immunohistochemistry, immunogenotyping, and histology. Gastric and colonic FLs presented in submucosal to subserosal areas, whereas duodenal ones presented in the mucosal to submucosal layers. Immunohistochemical analysis revealed that duodenal FLs exhibited the following phenotypes:and loose CD21 network (duodenal pattern). Gastric/colonic FLs exhibited the following phenotypes:, and a dense CD21 network (nodal pattern). Expression of AID and CD27 in lymphoma cells and the CD21 network pattern were considerably different between duodenal FLs and gastric/colonic ones. Moreover, in situ hybridization revealed that, in the duodenal FLs, BACH2 was expressed at the periphery of the tumor follicle and tumor villi. The number of immunoglobulin heavy-chain variable domains VH4 and VH5 were higher in duodenal follicular lymphomoas than in gastric FLs. The lymphoma cells of duodenal FLs are different from those of gastric/ colonic FLs, and duodenal FL is distinct even within the gastrointestinal tract. Somatic hypermutation in immunoglobulin genes and CD27 expression are hallmarks of memory B cells. We suggest that duodenal FL cells are in the memory B-cell stage, and require BACH2 instead of AID for ongoing mutation.

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confidence: 99%

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

et al. 2013

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“…Patients with grade 3 follicular lymphoma were excluded from this study since these cases are typically managed as diffuse large B cell lymphoma [31] . A subset of the 80 patients examined were also subjects of our previous studies [33][34][35][36] . Of the 80 patients identified, 30 were excluded since they did not undergo 18F-FDG-PET.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement

Iwamuro

Okada²,

Takata³

et al. 2012

WJG

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AIM:To investigate the capacity for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma. METHODS:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October 2011. Data for endoscopic, radiological, and biological examinations performed were retrospectively reviewed from clinical records. A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value (SUVmax). Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed, patients were subdivided into two groups. To identify potential predictive factors for 18F-FDG positivity, these two groups were compared with respect to gender, age at diagnosis of lymphoma, histopathological grade, pattern of follicular dendritic cells, mitotic rate, clinical stage, soluble interleukin-2 receptor levels detected by 18F-FDG-PET, lactate dehydrogenase (LDH) levels, hemoglobin levels, bone marrow involvement, detectability of gastrointestinal lesions by computed tomography (CT) scanning, and follicular lymphoma international prognostic index (FLIPI) risk. ORIGINAL ARTICLE RESULTS:Involvement of follicular lymphoma in the stomach, duodenum, jejunum, ileum, cecum, colon, and rectum was identified in 1, 34, 6, 3, 2, 3, and 6 patients, respectively. No patient had esophageal involvement. In total, 19/41 (46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal tract. In contrast, false-negative 18F-FDG uptake was detected in 24 patients (58.5%), while false-positive 18F-FDG uptake was detected in 5 patients (12.2%). In the former case, 2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal tract. In patients with 18F-FDG avidity, the SUVmax value of the involved gastrointestinal tract ranged from 2.6 to 17.4 (median: 4.7). For the 18F-FDG-negative (n = 22) and -positive (n = 19) groups, there were no differences in the male to female ratios (10/12 vs 4/15, P = 0.186), patient age (63.6 ± 2.4 years vs 60.1 ± 2.6 years, P = 0.323), presence of histopathological grade 1 vs 2 (20/2 and 17/2, P = 1.000), follicular dendritic cell pattern (duodenal/nodal: 13/5 vs 10/3, P = 1.000), mitotic rate (low/ partly high, 14/1 vs 10/3, P = 0.311), clinical stage according to the Ann Arbor system (stages ⅠE and ⅡE/ other, 15/7 vs 15/4, P = 0.499), clinical stage according to the Lugano system (stages Ⅰ and Ⅱ-1/other, 14/8 vs 14/5, P = 0.489), soluble interleukin-2 receptor levels (495 ± 78 vs 402 ± 83, P = 0.884), LDH levels (188 ± 7 vs 183 ± 8, P = 0.749), hemoglobin levels (13.5 ± 0.3 vs 12.8 ± 0.4, P = 0.197), bone marrow involvement (positive/negative, 1/8 vs 1/10, P = 1.000), detectability by CT scanning (positive/negative, 1/16 vs 4/13, P = 0.335...

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“…Polymerase chain reaction was performed according to standard procedures as described previously. [19][20][21][22] The primers used for immunoglobulin heavy chain gene amplification were as follows: [19][20][21] The primers used for T-cell receptor gamma gene amplification were as follows. 22 for …”

Section: Polymerase Chain Reaction For Detecting Immunoglobulin Heavymentioning

confidence: 99%

Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease

Kojima²,

et al. 2009

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Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

Abstract: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.

Cited by 67 publications

References 34 publications

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement

Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease

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