Duodenal Ferritin Content and Structure

Halliday, June W.; Mack, Ulrich; Powell, Lawrie W.

doi:10.1001/archinte.1978.03630320047016

Cited by 20 publications

(2 citation statements)

References 23 publications

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“…If ferritin receptors are present in the basolateral membrane of intestinal cells it is possible that these could sense body iron stores via circulating serum ferritin. A positive correlation between serum ferritin and duodenal ferritin has been shown in human subjects (62,64).…”

Section: Regulation Of Iron Absorptionmentioning

confidence: 88%

“…Although a correlation exists between serum ferritin and duodenal ferritin in haemochromatosis, Halliday et at. showed that duodenal ferritin was lower at all levels of serum ferritin compared to normal subjects (62). Inappropriately low, or absent (63), duodenal ferritin levels may contribute to the hyperabsorption of iron if the ferritin partition concept (49) can be applied to intestinal cells (62)(63)(64).…”

Section: Iron Slores and Iron Absorptionmentioning

confidence: 99%

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Mechanisms and Regulation of Intestinal Uptake and Transfer of Iron

1989

Acta Paediatrica

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Flanagan, P. R. (Departments of Medicine and Biochemistry, University of Western Ontario, London, Ontario, Canada). Mechanisms and regulation of intestinal uptake and transfer of iron. Despite much research over the past fifty years, the precise details of intestinal iron absorption remain unclear. The lack of understanding extends both to the specific biochemical mechanisms of transport as well as the means by which these are regulated. Iron in several dietary forms must be digested and processed in the intestinal lumen, taken up across the mucosal brush border membrane, transported through the intestinal absorptive cell, accomplish a second transmembrane passage across the basolateral membrane and, finally, be transported to sites of iron metabolism and storage within the body. Recent findings in several of these areas are reviewed. Evidence is presented to support the involvement, or non‐involvement, of several intestinal iron‐binding components in iron transport. In the future, the application of molecular biology to the investigation of intestinal iron metabolism will undoubtedly increase understanding of absorption mechanisms and their regulation.

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Section: Regulation Of Iron Absorptionmentioning

confidence: 88%

Section: Iron Slores and Iron Absorptionmentioning

confidence: 99%

Mechanisms and Regulation of Intestinal Uptake and Transfer of Iron

1989

Acta Paediatrica

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Maternal and fetal iron measurements in a hemochromatotic pregnancy

Baynes¹,

Meyer²,

Bothwell³

et al. 1991

American J Hematol

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The findings in the cord blood sample of an infant from a treated hemochromatotic mother of a raised transferrin saturation (88%) and a raised ferritin concentration (250.2 micrograms/L) together with elevated maternal values (66% and 91.6 micrograms/L, respectively) yet a normal total placental iron content (26.9 mg) suggested that in common with gastrointestinal mucosal cells and reticuloendothelial cells in hemochromatosis, the placental cell may exhibit an abnormality of iron storage and transport.

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A career forged in iron

Powell

2014

Hepatology

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Duodenal Ferritin Content and Structure

Cited by 20 publications

References 23 publications

Mechanisms and Regulation of Intestinal Uptake and Transfer of Iron

Mechanisms and Regulation of Intestinal Uptake and Transfer of Iron

Maternal and fetal iron measurements in a hemochromatotic pregnancy

A career forged in iron

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