Duodenal biopsy in malabsorption-A clinicopathological study

Karegar, Manjusha; Kothari, Kanchan; Mirjolkar, Amit S

doi:10.5958/2394-6792.2016.00039.9

Cited by 4 publications

(3 citation statements)

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“…Manjusha had studied 50 duodenal biopsies over a period of one year in a tertiary care hospital and he found 28% celiac disease and 4% tropical sprue cases. 17 The percentage of celiac disease in his study almost exactly corresponds with our figures. A study done by Tariq 18 comprised of 100 cases over a six month duration revealed 46% celiac disease, 38% nonspecific duodenitis and 2% giardiasis with 14% normal cases.…”

Section: Discussionsupporting

confidence: 87%

Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

Zafar

Mudassir

Nazir

et al. 2019

JSTMU

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Objective: Endoscopic duodenal biopsies constitute a significant load of specimens in the histopathological section of a tertiary care hospital. Most of these diseases comprise non-neoplastic lesions causing significant morbidity. The purpose of this study was to see the frequency of these diseases in our patient population and to compare and analyze our results with similar other studies. Methods: In this retrospective study records of all duodenal biopsies reported from Feb 2017- Jan 2018 were retrieved. Both non neoplastic and neoplastic conditions along with biopsies with unremarkable findings were included. Various histological parameters like villous blunting, IEL count per 100 enterocytes, crypt hyperplasia, inflammation in lamina propria, and presence of microorganisms, any dysplasia or malignancy were studied. Data was statistically analyzed using SPSS v.23. Results: A total of 159 duodenal biopsies were included in the study. Normal duodenal morphology was noted in 85 (53.45%) cases while 74 (46.83%) cases revealed abnormal duodenal pathology. There were 46 (28.93%) cases consistent with celiac disease. Twenty eight (17.61%) cases were of other duodenal pathologies of which non-specific duodenitis was most common. There were 22 (13.83%) cases of duodenitis and 2 (1.26%) cases were of duodenal ulcer. One case (0.62%) each was seen of Brunner gland hyperplasia, adenocarcinoma, signet ring carcinoma and one case was of metastatic adenocarcinoma. Conclusion: In our study we found a significant percentage of 46.83% exhibiting abnormal duodenal pathology. Cases consistent with celiac disease were 28.93% while 13.83% of the cases had duodenitis. The percentage of malignant cases was minimal (1.88%).

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Section: Discussionsupporting

confidence: 87%

Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

Zafar

Mudassir

Nazir

et al. 2019

JSTMU

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“…Manjusha Milind Karegar et al observed 28% cases of celiac disease with slight female preponderance. 9 The high proportion CD in the present study as compared to the prevalence rate of 1% in general population 10 can be attributed firstly to the fact that our study was conducted on the symptomatic patients and secondly to the overlapping features of other conditions like autoimmune enteropathy, tropical sprue and many other with increased IEL and/or villous atrophy and crypt hyperplasia that can mimic Celiac disease on biopsy. Regular follow up, mandatory anti transglutaminase antibodies estimation, repeat biopsy is required to filter out the overlapping conditions.…”

Section: Gastric Biopsymentioning

confidence: 59%

Histopathological spectrum of lesions in gastrointestinal endoscopic biopsy: A prospective study of 500 cases

Sharma¹,

Kumari²,

Sharad³

et al. 2020

IJPO

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Lesion of the gastrointestinal tract is a very common condition encountered in medical science. An endoscopic biopsy is a favourable tool for early diagnosis and management of these conditions. The aim of the work is to study the histopathological spectrum of gastrointestinal endoscopic biopsy. In a prospective study of 500 biopsies, Formalin-fixed tissue was processed and stained with Hematoxylin-Eosin stain and studied under the microscope. A wide spectrum of neoplastic and non-neoplastic lesions was noted with male preponderance in most of the gastrointestinal tract. The commonest age group was 6 decades of life. Mean age being 51.83years. Predominant sample collected was from stomach accounting for 36.6% of total gastrointestinal biopsies. The ratio between non-malignant: malignant lesion was 2.7:1. Majority of the malignancy was Adenocarcinoma seen in 71 out of 135 cases closely followed by Squamous cell carcinoma (62/135). Most of the oesophageal malignancy was squamous cell carcinoma whereas adenocarcinoma was common in rest of the gastrointestinal tract. Gastritis was the commonest non-neoplastic lesion. Celiac disease was common in our study. Eight cases of adenomatous polyp identified, four of them showed high-grade dysplasia. Celiac disease and inflammatory bowel disease need further studies as there were many overlapping features which make a definitive diagnosis difficult. Endoscopy itself is insufficient in the diagnosis and management of gastrointestinal tract disease and biopsy must be performed in all cases of suspected endoscopic finding. Conditions like Barrett’s oesophagus, Celiac disease, Inflammatory Bowel Disease and high-grade dysplasia needs timely intervention to avoid more serious complications.

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“…Of a total of 1063 articles, 12 full text articles with detail comparative analyses of clinical or endoscopic or histological features of CD and TS were identified and included (Table ). Finally, the data analyzed and described in this systematic review include 254 patients with CD and 161 with TS . Both children and adult patients with CD and TS were considered in this systematic review.…”

Section: Resultsmentioning

confidence: 99%

Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review

Sharma

Baloda

Gahlot

et al. 2018

J of Gastro and Hepatol

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Duodenal biopsy in malabsorption-A clinicopathological study

Cited by 4 publications

References 0 publications

Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

Histopathological spectrum of lesions in gastrointestinal endoscopic biopsy: A prospective study of 500 cases

Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review

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