Duodenal and Jejunal Biopsies

Doniach, I.; Shiner, Margot

doi:10.1016/s0016-5085(19)35791-9

Cited by 102 publications

(33 citation statements)

References 3 publications

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“…The mucosal lesion of sprue may be spotty, a fact noted by Doniach and Shiner (1957) and by Rubin and his host (1960), but often not taken into account by others. In the same biopsy specimen (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Other sections were stained with haematoxylin and eosin; the epithelial height was independently graded by three observers from normal (4) to very flat (1). Another portion of the specimen was studied by the dissecting microscope, classified by the scheme of Doniach and Shiner (1957), and photographed. All slides were reviewed by at least two observers, one of whom knew nothing about the patients.…”

Section: Methodsmentioning

confidence: 99%

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Functional histochemistry of the small bowel mucosa in malabsorptive syndromes

Spiro¹,

Filipe²,

Stewart³

et al. 1964

Gut

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Functional histochemistry of the small bowel mucosa in malabsorptive syndromes

Spiro¹,

Filipe²,

Stewart³

et al. 1964

Gut

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“…The jejunal mucosal lesion in coeliac disease is characterized by an immature and irregular absorptive epithelium and an intense inflammatory cell infiltrate consisting mainly of lymphocytes and plasma cells with loss of villous structure (Doniach & Shiner, 1957). Two main hypotheses have been suggested to explain the pathogenesis of this lesion (Booth, 1970).…”

Section: Introductionmentioning

confidence: 99%

Enzyme Activities and Properties of Lysosomes and Brush Borders in Jejunal Biopsies from Control Subjects and Patients with Coeliac Disease

1975

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1. Reduced activities of four enzymes from brush borders were found in intestianl biopsies from patients with untreated coeliac disease. The activities returned towards control values after treatment by gluten withdrawal. Parallel changes were noted for the cytosol enzyme lactate dehydrogenase. 2. Measurement of brush-border integrity by differential centrifugation of biopsy extracts indicated increased fragility of the brush borders in biopsies from untreated patients. Normal values were obtained for biopsies from treated patients. 3. Increased activites of six acid hydrolases (lysosomal enzymes) were found in biopsies from untreated coeliac patients. Normal values were obtained for biopsies from treated patients. 4. Assement of lysosomal integrity by assay of latent N-acetyl-beta-glucosaminidase and of sedimentable activity of four acid hydrolases demonstrated increased lysosomal fragility in untreated coeliac mucosa. These lysosomal changes return to within the normal range after treatment by gluten withdrawal. 5. The lysosomal changes are consistent with their having a pathogenic role in the enterocyte damage of coeliac disease. Possible mechanisms for the lysosomal changes are discussed.

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“…The published photomicrographs are not of sufficient magnification to exclude the presence of gastric epithelium. Shiner (1957) took mucosal specimens from the duodenum by an aspiration biopsy tube; the biopsies were taken from the first or second part of the duodenum, and the histological study of them by Doniach and Shiner (1957) does not distinguish between these different sites of origin. In most of the biopsies the mucosa was normal and the epithelium well preserved.…”

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confidence: 99%

Gastric epithelium in the duodenum

James¹

1964

Gut

143

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EDITORIAL SYNOPSIS It has been found that a 'gastric' type of epithelium tends to develop in the first part of the duodenum in patients with duodenal ulceration and is found in the second part of the duodenum in a patient with the Zollinger-Ellison syndrome. It is likely that 'gastric' epithelium appears when the duodenal acidity is high and it is resistant to ulceration.The stomach is normally lined by one kind of epithelium and the duodenum by another. Islands of intestinal epithelium have long been known to occur in the stomach, particularly when gastric acidity is low: this paper describes islands of gastric epithelium in the duodenum; they are especially common when gastric, and hence duodenal, acidity is high. These anomalies mirror each other, and the conditions which bring them about throw light, it will be suggested, upon the pathogenesis of peptic ulceration and the determination of its site.Taylor (1927), reviewing heterotopia in the alimentary tract, described two instances of gastric epithelium in the duodenum. They were found among 150 necropsies, and were recognizable as slightly raised patches. Histological examination showed these to be covered by well-preserved gastric epithelium and to contain gastric glands with both chief and parietal cells; Brunner's glands were absent from the patches. In both cases the patches were found in the first part of the duodenum near the pylorus, and in one there was a duodenal ulcer. The presence of gastric glands places these patches in a different category from those described in this paper, where only the epithelium was abnormal. Patzelt (1936) reviewed the histology of the pyloro-duodenal region in animals and man and quoted descriptions which showed that the line of epithelial demarcation was not always sharp, there being islands of intestinal epithelium on the gastric side of the pylorus and, much more rarely, of gastric epithelium on the intestinal side. His article contains an illustration of one such 'Magenepithelinsel' found in the duodenum of a woman; the island appears to cover an inflammatory polyp containing a lymph follicle; no gastric glands were present.

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Duodenal and Jejunal Biopsies

Cited by 102 publications

References 3 publications

Functional histochemistry of the small bowel mucosa in malabsorptive syndromes

Functional histochemistry of the small bowel mucosa in malabsorptive syndromes

Enzyme Activities and Properties of Lysosomes and Brush Borders in Jejunal Biopsies from Control Subjects and Patients with Coeliac Disease

Gastric epithelium in the duodenum

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