Dumping Syndrome Following Pyloroplasty

Bowers, Ralph F.; Stockard, Charles G.

doi:10.1001/archsurg.1966.01320190041009

Cited by 9 publications

(1 citation statement)

References 3 publications

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“…Consistent with this, the PV group, in comparison to the PS group in the treatment arm of the study, did not over-eat relative to baseline levels in any of the experimental paradigms. The compensatory hyperphagia exhibited in the PS group during weeks 3 and 4 of the treatment arm of the study may be due to “dumping syndrome” or the accelerated emptying of gastric contents into the small bowel associated with the pyloroplasty drainage procedure (Bowers and Stockard, 1966 ). This compensatory hyperphagia is not present in the PV group; thereby, attesting to the effectiveness of SDV to exert a chronic anorexigenic effect.…”

Section: Discussionmentioning

confidence: 99%

Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

et al. 2018

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Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r−/−).Subjects/Methods: In two separate studies, we examined the efficacy of bilateral subdiaphragmatic vagotomy (SDV) with pyloroplasty in the prevention and treatment of obesity in Mc4r−/− mice.Results: In the first study, SDV prevented >20% increase in body weight (BW) associated with this genotype. This was correlated with a transient reduction in overall food intake (FI) in the preventative arm of the study. Initially, SDV mice had reduced weekly FI; however, FI normalized to that of controls and baseline FI within the 8-week study period. In the second study, the severe obesity that is characteristic of the adult Mc4r−/− genotype was significantly improved by SDV with a magnitude of 30% loss in excess BW over a 4-week period. Consistent with the first preventative study, within the treatment arm, SDV mice also demonstrated a transient reduction in FI relative to control and baseline levels that normalized over subsequent weeks. In addition to the accompanying loss in weight, mice subjected to SDV showed a decrease in respiratory exchange ratio (RER), and an increase in locomotor activity (LA). Analysis of the white fat-pad deposits of these mice showed that they were significantly less than the control groups.Conclusions: Altogether, our data demonstrates that SDV both prevents gain in BW and causes weight loss in severely obese Mc4r−/− mice. Moreover, it suggests that an important aspect of weight reduction for this type of monogenic obesity involves loss of signaling in vagal motor neurons.

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Section: Discussionmentioning

confidence: 99%