Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings

Kumazoe, Hiroyuki; Nagamatsu, Yoshinori; Nishi, Tatsuya; Kimura, Yusuke; Nakazono, Takahiko; Kudo, Sho

doi:10.1007/s11604-008-0289-9

Cited by 6 publications

(15 citation statements)

References 11 publications

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“…Microscopically, the tumor is characterized by multivacuolated cells with eccentric nuclei and granular eosinophilic cytoplasm, univacuolated cells with peripheral nuclei, and smaller round cells with granular cytoplasm. The hypervascularity and the presence of cells with eosinophilic granular cytoplasm full of mitochondria give hibernomas their brown color [4,6,18]. From an histological point of view this entity must be distinguished from granular cell tumor, that is a benign peripheral nerve derived tumor composed of granular cells rich in mitochondria.…”

Section: Discussionmentioning

confidence: 99%

“…Histopathologic evaluation of hibernomas, as previously described, is well-established and pathognomonic. On the contrary, CT and MRI features are not specific and vary with the nature and amount of lipid component [4,12,18,19,22,23]. Non contrast CT usually demonstrates a well-demarcated soft tissue mass of predominantly low attenuation which is close but not identical to subcutaneous fat.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of author's knowledge only three series [5-7] and several case reports [8-18] have exhibited the imaging characteristics of hibernomas. The present study, being the largest in the imaging of hibernomas, highlights the spectrum of imaging appearances (CT/MRI) of twelve histologically proven cases of hibernomas and stresses the positive impact of imaging in the pre-operative planning when a complex fatty mass is encountered.…”

Section: Introductionmentioning

confidence: 99%

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Imaging of hibernomas: A retrospective study on twelve cases

et al. 2011

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BackgroundTo analyze the imaging features of hibernomas on computed tomography (CT) and magnetic resonance (MRI).MethodsTwelve hibernomas were retrospectively assessed with CT and MR imaging and compared to the histology of the specimenResultsNine females and three males with a mean age of 30 years were included. Ten tumors occurred in the thigh and two affected the subcutis of the periscapular and buttock regions. On eight CT scans, seven (87,5%) lesions were homogeneous and mildly to moderately hyperdense compared to subcutaneous fat while one lesion was heterogeneous with mixed hypo and hyperattenuating areas. On six T1W images, five (83,3%) lesions appeared homogeneous and hypointense relative to subcutaneous fat and one was heterogeneous. Incomplete fat suppression was depicted in all cases. All lesions displayed marked enhancement. Large intratumoral vessels were depicted in three of the 12 (25%) cases. Septations were depicted on four of the eight unenhanced CT and on all six MRI examinations.ConclusionsHibernoma usually appears hypodense and hypointense relative to subcutaneous fat on pre-contrast CT and MR T1W with variable enhancement patterns and incomplete fat suppression on STIR or fat-saturated sequences. These characteristics relate directly to the presence of brown fat. However, atypical findings such as heterogeneous patterns of mixed fatty and non fatty components on unenhanced CT and MR T1W can be also encountered. Absence of large intratumoral vessels should not exclude hibernomas from the differential diagnosis of regional lipomatous tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Imaging of hibernomas: A retrospective study on twelve cases

et al. 2011

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“…Esta última, con algunas secuencias particulares de supresión grasa, aporta datos concluyentes para la identificación del componente graso. 4,[7][8][9] En los hibernomas, la TC demuestra lesiones bien definidas, cuando su localización es muscular. Se observa realce difuso con contraste endovenoso.…”

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Hibernoma: tumor retroperitoneal de grasa parda. Informe de un caso pediátrico

Collado

Sierre²,

Bosalec³

et al. 2011

Arch Argent Pediat

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Presentación de casos clínicos RESUMENEl hibernoma es un raro tumor benigno de los tejidos blandos, compuesto por grasa parda, tejido que predomina en animales que hibernan y de allí su nombre. Debido a su infrecuencia en Pediatría y a su diagnóstico complejo, presentamos un paciente de 3 meses de edad, con diagnóstico de tumor abdominal. Los exámenes por ecografía y tomografía computada demostraron un tumor retroperitoneal de carácter infiltrativo, vascularizado y con características lipomatosas. La exéresis del tumor permitió arribar al diagnóstico histopatológico de hibernoma o tumor de grasa parda. En esta presentación se describen las características del hibernoma, como tumor infrecuente en niños, y se revisan los tumores de tejido graso, según su frecuencia en Pediatría. Palabras clave: hibernoma, tumor de tejido adiposo, tumor hipervascularizado, Pediatría.

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“…Welldifferentiated liposarcoma resembles it on low-power examination, but closer inspection shows scattered tumor cells with large, deep-staining nuclei. [20] Due to this it is especially important to perform a differential diagnosis with lipoma, fibroma, neurofibroma, angiolipoma, and even with liposarcoma, by clinically and radiologically studies, making a differential diagnoses with myxoid liposacorm, angiomyolipoma and mesenteric panniculitis; [12] so myxoid liposarcoma may present a clinical picture and radiological findings similar to hibernoma and lipoblastoma, but it is associated with infiltrating growth, presenting cellular atypia and is extremely infrequent in the pediatric age; [20] the angiomyolipoma is a vascular tumour with striated muscle cells and adipose tissue, [18,21] and characteristically found at the renal level.…”

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confidence: 99%

A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

Costa

Gallud

Rayón

et al. 2018

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Background: Hibernoma or lipoma of brown fat is a rare benign tumor, representing 1.6% of the neoplasms of this tissue. Because of its histological characteristics can be wrongly classified as liposarcoma, therefore a correct differential diagnosis is necessary to provide appropriate treatment. Case presentation: The patient on which this case study is based is a 44-year-old male with a painless soft mass in his axilla located by his 4 th and 5 th ribs. The resected specimen did not have the classic macroscopic features of lipoma or fibrolipoma.Microscopically, the report described a proliferation of unilocular adipocytes with eccentric nucleus and, in less frequency, multilocular adipocytes with central nucleus. He had no recurrence after excision. Conclusions: Despite radiology studies and other technologies such as magnetic resonance imaging, computerized axial tomography (CAT), etc., the clinical diagnosis of hibernoma could be difficult. Lipoma-like hibernoma only have a few multilocular cells and can be wrongly classified as liposarcoma. Well-differentiated liposarcoma resembles it on low-power examination. Due to this it is especially important to perform a differential diagnosis with lipoma, fibroma, and even with liposarcoma. In this study we describe the histological features, the molecular markers and cytogenetic aspects that contribute to differentiate hibernoma from others tumors.

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Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings

Cited by 6 publications

References 11 publications

Imaging of hibernomas: A retrospective study on twelve cases

Imaging of hibernomas: A retrospective study on twelve cases

Hibernoma: tumor retroperitoneal de grasa parda. Informe de un caso pediátrico

A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

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