Duloxetine for pain in fibromyalgia in adults: a systematic review and a meta-analysis

Lian, Yongyun; Wang, Yi; Zhang, Ying; Yang, Chen

doi:10.1080/00207454.2019.1664510

Cited by 32 publications

(28 citation statements)

References 19 publications

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“…The serotonergic pathway is a therapeutic target for several chronic pain-related conditions like fibromyalgia and neuropathic pain [156]. For chronic pain management, tricyclic antidepressants are the most commonly used antidepressants.…”

Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

“…For chronic pain management, tricyclic antidepressants are the most commonly used antidepressants. However, the efficacy of selective serotonin (SSRI) and serotonin-noradrenaline reuptake inhibitors (SNRI) to decrease pain and reduce the need for opioid therapy has been studied [156,157,158].…”

Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

“…These neurons release serotonin and noradrenaline as their neurotransmitters and it is thought that dysregulation in this descending tract may impede the pain-relief activity [158]. A recent meta-analysis of seven studies showed the superiority of duloxetine over placebo to decrease pain by at least 30% in patients with fibromyalgia [156].…”

Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

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An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens

Paredes

Cantillo

Candido

et al. 2019

IJMS

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Ovarian hormones play an important role in pain perception, and are responsible, at least in part, for the pain threshold differences between the sexes. Modulation of pain and its perception are mediated by neurochemical changes in several pathways, affecting both the central and peripheral nervous systems. One of the most studied neurotransmitters related to pain disorders is serotonin. Estrogen can modify serotonin synthesis and metabolism, promoting a general increase in its tonic effects. Studies evaluating the relationship between serotonin and disorders such as irritable bowel syndrome, fibromyalgia, migraine, and other types of headache suggest a clear impact of this neurotransmitter, thereby increasing the interest in serotonin as a possible future therapeutic target. This literature review describes the importance of substances such as serotonin and ovarian hormones in pain perception and illustrates the relationship between those two, and their direct influence on the presentation of the aforementioned pain-related conditions. Additionally, we review the pathways and receptors implicated in each disorder. Finally, the objective was to stimulate future pharmacological research to experimentally evaluate the potential of serotonin modulators and ovarian hormones as therapeutic agents to regulate pain in specific subpopulations.

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Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

Section: Serotonin Modulating Analgesicsmentioning

confidence: 99%

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An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens

Paredes

Cantillo

Candido

et al. 2019

IJMS

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“…FM is characterized by widespread pain, along with multiple other symptoms including fatigue and cognitive fog [53][54][55][56][57]. As in CFS, a multidisciplinary approach to management is recommended, often accessed through chronic pain clinics.…”

Section: Comorbid Pain Fatigue and "Cognitive Fog"mentioning

confidence: 99%

“…Pregabalin exerts its therapeutic effect by modulating cortical excitability, increasing the cortical silent period and the short intracortical inhibition [60]. Meanwhile, a meta-analysis of seven randomized, double-blind, placebo-controlled trials investigating the use of duloxetine for FM found it to be more effective than placebo at improving pain, but with considerable risk of side effects [57]. The analgesic effect of duloxetine may be linked to changes in frontal quantitative EEG [61].…”

Section: Comorbid Pain Fatigue and "Cognitive Fog"mentioning

confidence: 99%

Management of functional neurological disorder

et al. 2020

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Functional neurological disorder (FND) is a common cause of persistent and disabling neurological symptoms. These symptoms are varied and include abnormal control of movement, episodes of altered awareness resembling epileptic seizures and abnormal sensation and are often comorbid with chronic pain, fatigue and cognitive symptoms. There is increasing evidence for the role of neurologists in both the assessment and management of FND. The aim of this review is to discuss strategies for the management of FND by focusing on the diagnostic discussion and general principles, as well as specific treatment strategies for various FND symptoms, highlighting the role of the neurologist and proposing a structure for an interdisciplinary FND service.

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Antidepressant analgesics in the management of chronic pain

Gurba¹,

Haroutounian²

2022

Clinical Pain Management

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Duloxetine for pain in fibromyalgia in adults: a systematic review and a meta-analysis

Cited by 32 publications

References 19 publications

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens

An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens

Management of functional neurological disorder

Antidepressant analgesics in the management of chronic pain

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