Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function

Abstract

The susceptibility of African American recipients to acute rejection and to DGF was not confirmed to be associated with DARC alleles or genotype. Future studies should exclude a potential role of donor-related DARC in transplant outcomes.

Shedding light on DARC: the role of the Duffy antigen/receptor for chemokines in inflammation, infection and malignancy

“…They found that the Duffy-negative phenotype was commonly associated with rejection in the setting of delayed graft function, but there was no correlation with outcome beyond this subset. A later study confirmed no association between any Duffy phenotypes and acute rejection, or delayed graft function [18]. These studies were both small, and although they were looking for a large difference in outcomes, they may have been insufficiently powered to detect any significance.…”

Immune factors influencing ethnic disparities in kidney transplantation outcomes

“…Similarly, Mange et al were not able to demonstrate an association between recipient-related allelic variants of the DARC gene and acute rejection among 181 African-American recipients of cadaveric renal allografts [88].…”

Immunosuppression in high-risk transplantation

“…Although this difference is multifactorial, African-Americans apparently have heightened immune reactivity with increased numbers of activated T cells, blastogenesis and increased costimulatory responses [39,40]. In addition, Lewis and Duffy red cell antigen receptor differences in African-Americans compared with whites have also been implicated as playing a role in the increased immunogenicity of African-Americans [41,42]. These blood type differences may explain the fact that, in comparison to whites, African-Americans experience a 1.5-year longer waiting time for deceased donors [16], and waiting time is known to negatively impact graft survival results [43].…”