Ductus Arteriosus Aneurysm with Organized Thrombus in a Neonate: Echocardiograms from Diagnosis to Resolution

Masood, Syed Asif; Bokowski, John; Kazmouz, Suhaib; Amin, Zahid

doi:10.14503/thij-14-4128

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…There have been eight cases of newborn-onset DAA complicated with pulmonary artery thromboses, including the present patient (►Table 1). [9][10][11][12][13] One prenatally diagnosed case resulted in stillbirth. 14 All eight diagnosed cases after birth survived without recurrence or complications.…”

Section: Discussionmentioning

confidence: 99%

Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn

Shirozu

Ichiyama

Ishimura

et al. 2023

AJP Rep

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Ductus arteriosus aneurysm (DAA) asymptomatically occurs in newborn infants and resolves spontaneously. High-risk DAA with compression, rupture and thrombosis requires early surgical intervention. Newborn infants have the highest risk of thrombosis among pediatric patients, but the genetic predisposition is difficult to determine in infancy. We herein report a neonatal case of massive thromboses in DAA and pulmonary artery. Desaturation occurred in an active full-term infant two days after birth. Echocardiography and contrast-enhanced computed tomography indicated thrombotic occlusion of the DAA and pulmonary artery thrombus. Urgent thrombectomy and ductus resection were successfully performed. After six months of anticoagulant therapy, the dissociated low plasma activity levels of protein S from protein C suggested protein S deficiency. A genetic study of PROS1 identified a heterozygous variant of protein S K196E, a low-risk variant of thrombophilia in Japanese populations. There have been seven reported cases with neonatal-onset symptomatic thromboses of DAA involving the pulmonary artery. All survived without recurrence after surgical intervention in five and anticoagulant therapy alone in two. Two newborns had a heterozygous methylenetetrahydrofolate reductase variant, but information on thrombophilia was not available for any other cases. A genetic predisposition may raise the risk of DAA thrombosis, leading to rapid progression.

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Section: Discussionmentioning

confidence: 99%

Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn

Shirozu

Ichiyama

Ishimura

et al. 2023

AJP Rep

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“…Aspirin is a well-known antiplatelet agent that can prevent arterial thrombosis, but its efficacy in preventing DAA thrombosis is unclear. Masood reported one successful use of aspirin in DAA patients with thrombus formation [11] . Therefore, the role of aspirin in DAA remains uncertain and should be individualized based on the risk of thrombosis, bleeding, and preferences.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic congenital ductus arteriosus aneurysm in a newborn: Case by approach

Huynh,

Pham,

et al. 2023

Radiology Case Reports

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“…[1][2][3] However, ductal aneurysms may present with complications including spontaneous rupture with fatal outcome, compression of the surrounding structures mainly the airways and thrombus formation. [4][5][6][7] Extensive thrombosis of aneurysmal ductus arteriosus is estimated to be very rare, with only few case reports in the literature, and usually associated with catastrophic outcome. 8 Due to diagnostic difficulties and isolated cases, we believe that ductus arteriosus aneurysms with a simple course or about more specifically thrombosed ductus arteriosus aneurysms are largely under-diagnosed and underreported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Antenatal occlusion of a ductal arteriosus aneurysm: a potential postnatal surgical emergency. Case report and literature review

et al. 2020

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Symptomatic presentation of ductal arteriosus aneurysm is usually a consequence of associated complications, including thromboembolism, infection, and compression of adjacent structures. In this case report, we present a thrombosed ductal aneurysm that developed antenatally with further postnatal progression of the thrombus and complete occlusion of the left pulmonary artery. Urgent surgical thrombectomy was successful and the post-operative course was uneventful.

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Ductus Arteriosus Aneurysm with Organized Thrombus in a Neonate: Echocardiograms from Diagnosis to Resolution

Cited by 6 publications

References 4 publications

Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn

Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn

Asymptomatic congenital ductus arteriosus aneurysm in a newborn: Case by approach

Antenatal occlusion of a ductal arteriosus aneurysm: a potential postnatal surgical emergency. Case report and literature review

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