Ductal Carcinoma in situ of the breast in sclerosing adenosis encapsulated by a hamartoma: A case report

Abstract

HighlightsDuctal Carcinoma in situ in sclerosing adenosis encapsulated by a hamartoma is rare.The diagnosis is difficult due to the appearance of these combined lesions.Atypical appearance of a hamartoma may suggest a co-existing malignancy.

Ductal carcinoma in situ of the breast arising in encapsulated mammary hamartoma ; A case report

“…Among the past 17 cases, types of carcinoma associated with hamartoma are 1 combination of lobular and ductal, 1 mucinous, 4 lobular and 11 ductal, and cases with noninvasive carcinoma associated are only 3 cases. And among them, molecular subtype of cancer was indicated in only two cases, that is, one (12) showed both negative for estrogen and progesterone receptors, and HER2/neu negative same as our case, and the other (13) showed estrogen receptor weakly positive, progesterone receptor negative, and HER2/neu positive. Early detection of a minimal malignant change in the hamartoma is an important point.…”

“…Mendoiola et al had described the first case report of a malignant lesion associated with hamartoma in 1982 (2). Nami et al had reported 15 cases with coexistence of breast cancer and hamartoma (11) , and after the report Kai and Fukai were described a new case of carcinoma arising in mammary hamartoma in 2012 (12) and 2018 (13), respectively. Among the 17 cases past, 13 cases had carcinomas inside of the hamartoma.…”

“…Sclerosing adenosis often shows architectural distortion and is recently well known as the lesion of developing breast cancer (14) . Fukai et al reported a case in which ductal carcinoma in situ arose in sclerosing adenosis encapsulated by a hamartoma (13). It is important to perform periodical observation even if the prior diagnosis was benign hamartoma, and revelation the discordance of the lesion in each image, such as mammography, ultrasonography or MRI is also important to discover malignancies.…”

Cytological diagnosis of sclerosing adenosis of breast: Diagnostic challenges and literature review

“…Tubules can also be seen in low grade DC or DCIS but are not angular. The cells are relatively monomorphic with round nuclei and indistinct nucleoli but myoepithelial cells are absent 13 14 …”

Hamartoma of the breast in a man

“…Approximately 94% of mammary hamartomas present with specific characteristics on mammography, [14] namely as a round or oval mass, with uneven central density, and a smooth edge, accompanied by a transparent ring (consisting of a halo of fat). [15][16][17] Calcification within a hamartoma is relatively rare. When present, massive calcification is considered to be benign, while small sites of silty calcification are usually associated with malignancy.…”