Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment

Chapman, Judith-Anne W.; Miller, Naomi; Lickley, H. Lavina A.; Qian, Jin; Christens-Barry, William A.; Fu, Yuejiao; Yuan, Yan; Axelrod, David E.

doi:10.1186/1471-2407-7-174

Cited by 32 publications

(40 citation statements)

References 34 publications

(37 reference statements)

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confidence: 99%

“…DCIS is by definition not associated with stromal invasion but its biological potentials of invasion have been always in dispute. (12,13) DCIS is also classified into several types based on its potential to recur or develop into invasive carcinoma. (12) The correlation between these phenotypes and the status of neovascularization of each cases, however, has been little examined in DCIS.…”

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Vasohibin‐1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast

et al. 2010

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Vasohibin-1 is a recently identified negative feedback regulator of angiogenesis induced by VEGF-A and bFGF. In this study, we first evaluated mRNA expression of vasohibin-1 and CD31 in 39 Japanese female breast carcinoma specimens including 22 invasive ductal carcinoma (IDC) and 17 ductal carcinoma in situ (DCIS) using a real-time quantitative RT-PCR (QRT-PCR) with LightCycler system. In addition, we also immunolocalized vasohibin-1 and CD31 and compared their immunoreactivity to nuclear grades and histological grades of 100 carcinoma cases (50 IDC and 50 DCIS). There were no statistically significant differences of CD31 mRNA expression and the number of CD31 positive vessels between DCIS and IDC (P = 0.250 and P = 0.191, respectively), whereas there was a statistically significant difference in vasohibin-1 mRNA expression and the number of vasohibin-1 positive vessels in DCIS and IDC (P = 0.022 and P £ 0.001, respectively). There was a significant positive correlation between vasohibin-1 mRNA level and Ki-67 labeling index in DCIS (r 2 = 0.293, P £ 0.001). In addition, vasohibin-1 mRNA expression was correlated with high nuclear and histological grades in DCIS cases and a significant positive correlation was detected between the number of vasohibin-1 positive vessels and Ki-67 labeling index or nuclear grade or Van Nuys classification of carcinoma cells (P £ 0.001, respectively). These results all indicate the possible correlation between aggressive biological features in DCIS including increased tumor cell proliferation and the status of neovascularization determined by vasohibin-1 immunoreactivity. (Cancer Sci 2010; 101: 1051-1058 B reast cancer is one of the most common malignancies in woman worldwide and its morbidity has recently increased.(1) Numerous factors have been reported to be associated with development of breast cancer including angiogenesis. Angiogenesis or the formation of new blood vessel networks not only plays a pivotal role in human normal development, but also in pathological conditions such as inflammatory diseases and neoplasms.(2) A switch to the actively angiogenic phenotype is in general considered to be dependent upon an in situ balance between stimulatory and inhibitory factors of angiogenesis. (2,3) Therefore, numerous studies have been reported on the mechanisms of control or regulation of angiogenesis since the discovery of endothelium-specific proangiogenic factors, namely vascular endothelial growth factor (VEGF) and angiopoietin family proteins.(2) In addition, other molecules involved in this process of angiogenesis, including pigment epithelium derived factor (PEDF), platelet factor 4, angiostantin and endostatin, have been proposed as angiogenesis inhibitors. (2,4) Vasohibin-1 has been very recently identified as one of the first established negative feedback regulators of angiogenesis, from an extensive microarray analysis originally designed to identify genes up-regulated by VEGF in cultured vascular endothelial cells. (2,(5)(6)(7)(8) Vasohibin-1 was subsequently demonst...

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Vasohibin‐1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast

et al. 2010

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“…They showed that almost 50% of samples exhibit diversity of grade, be it different grade in the same duct, different grade in different ducts in the same area, or different grades in different areas [6]. This recognition of diversity is not formally acknowledged in current pathological reporting schemes, but it may have clinical significance, although a study using the worst or the predominant grade in the Van Nuys system did not show association with recurrence or development of invasive disease in those patients with heterogeneity [10].…”

Section: Abstract Dcis · Linear Progression · Parallel Progression ·mentioning

confidence: 87%

Progression of Ductal Carcinoma in Situ from the Pathological Perspective

Cunha¹,

Ornstein

Jones³

2010

Breast Care

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Ductal carcinoma in situ (DCIS) now represents up to 20% of breast cancer cases, yet its behaviour is still poorly understood. Morphological classifications go some way to predicting prognosis, but more sophisticated approaches are required to better tailor therapy to the individual. A number of biological molecules have been identified that appear to relate to prognosis and, in model systems, promote progression to invasive disease. Some of these, such as COX-2, provide real therapeutic opportunities, whilst other marker combinations are showing promise in categorising women according to risk. Gene expression studies have led to an emerging molecular classification of invasive breast cancer, and it is now evident that at least some of these molecular subtypes can be identified at the pre-invasive stage. The difference in frequency of these subtypes between DCIS and invasive cancer may hold clues as to the biological mechanisms underpinning disease transition. It is increasingly clear that the host microenvironment can have a major impact on disease behaviour, and as well as acting as potential predictive factors, the altered microenvironment phenotype also offers novel therapeutic opportunities.

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“…89 And nuclear densitometric features were significantly associated with nuclear grading. 90 In addition, the spatial arrangement of cell nuclei is important in distinguishing between differentiation degrees. Basavanhally et al 89 presented a multi-field-ofview method to integrate nuclear texture feature and spatial-arrangement feature for grading.…”

Section: Quantify Epithelial Features On Prognosismentioning

confidence: 99%

Computer-aided prognosis on breast cancer with hematoxylin and eosin histopathology images: A review

Chen

et al. 2017

Tumour Biol.

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With the advance of digital pathology, image analysis has begun to show its advantages in information analysis of hematoxylin and eosin histopathology images. Generally, histological features in hematoxylin and eosin images are measured to evaluate tumor grade and prognosis for breast cancer. This review summarized recent works in image analysis of hematoxylin and eosin histopathology images for breast cancer prognosis. First, prognostic factors for breast cancer based on hematoxylin and eosin histopathology images were summarized. Then, usual procedures of image analysis for breast cancer prognosis were systematically reviewed, including image acquisition, image preprocessing, image detection and segmentation, and feature extraction. Finally, the prognostic value of image features and image feature–based prognostic models was evaluated. Moreover, we discussed the issues of current analysis, and some directions for future research.

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Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment

Cited by 32 publications

References 34 publications

Vasohibin‐1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast

Vasohibin‐1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast

Progression of Ductal Carcinoma in Situ from the Pathological Perspective

Computer-aided prognosis on breast cancer with hematoxylin and eosin histopathology images: A review

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