Ductal Carcinoma In Situ: Biology, Diagnosis, and New Therapies

It Does Matter

“…Because the cancer is identified early and has not yet become invasive, the treatment for DCIS consists of surgery-lumpectomy or mastectomy. Surgery may be followed by radiation to the whole or partial breast depending on the tumor grade and amount of necrosis (Cutuli et al, 2009;Franceschini et al,2008;Goodwin, Parker, Ghersi, & Wilcken, 2009;Maass et al, 2009;Valenzuela & Julian, 2007). Depending on the receptor status of the tumor, antihormonal therapy may be offered.…”

Sentinel lymph node biopsy in selected cases of ductal carcinoma in situ

“…DCIS represents up to 20% of all breast cancers [1,2]. Conceptually, DCIS in any location is unable to develop metastases because it does not infi ltrate the basal membrane layer, but in practice, the incidence of lymph node metastasis of DCIS is approximately 1-5% [2][3][4] and may occur if there is an undetected invasive carcinoma.…”