Ductal Carcinoma In Situ Arising in a Benign Phyllodes Tumor: Report of a Case

Yamaguchi, Rin; Tanaka, Maki; Kishimoto, Yosuke; Ohkuma, Kazuaki; Ishida, M.; Kojiro, Masamichi

doi:10.1007/s00595-007-3562-0

Cited by 25 publications

(17 citation statements)

References 10 publications

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“…As there is no standard adjuvant treatment strategy for this type of disease, a variety of systemic therapies were applied to the various cases. In total, 6 cases received chemotherapy with various regimens (16,(19)(20)(21)(22)(23), 5 cases received radiotherapy (13,16,18,20), and 4 cases received endocrine therapy, 3 of which received tamoxifen (1,16,21) and 1 received tamoxifen and goserelin (19). Patient outcomes were described in 19 cases.…”

Section: Discussionmentioning

confidence: 99%

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Zhang

Guo

et al. 2016

Oncology Letters

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Abstract. Phyllodes tumor (PT) is a rare type of biphasic fibroepithelial neoplasm that may coexist with a breast tumor in rare cases. In the current study, a 52-year-old female presented with a left breast lump. Mammography and sonographic examination results suggested a diagnosis of malignant tumor. Histological analysis revealed a borderline PT with invasive ductal carcinoma (IDC) within the tumor. Due to the presence of a single micrometastasis in three of the sentinel lymph nodes, the patient underwent modified radical mastectomy. The excised tumor contained triple negative breast cancer; therefore, postoperative treatment included six cycles of chemotherapy and 25 cycles of radiotherapy. The patient exhibited no recurrence and no metastatic disease at the 23-month follow-up examination. Thus, the present study discussed the case of a female patient that presented with IDC within borderline PT and reviewed the literature on this rare type of neoplasm. Various types of breast carcinoma have been identified to coexist with PT in different masses; however, no standard therapeutic regimen has been established for the coexistence of PT and breast cancer in the same mass. The present study indicates that determination of an appropriate treatment strategy predominantly depends on the characteristics of the individual breast tumor.

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Section: Discussionmentioning

confidence: 99%

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

Zhang

Guo

et al. 2016

Oncology Letters

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“…The prognosis for cases of ductal carcinoma in situ within phyllodes tumors is generally favorable, with no deaths yet reported. Axillary lymph node dissection is not part of the standard treatment for phyllodes tumors as lymph node spread is rare, and may thus be restricted to patients suspected of having lymph node involvement by image diagnosis (5,9,16).…”

Section: Discussionmentioning

confidence: 99%

“…Malignant phyllodes tumors are treated like sarcomas and en bloc surgical resection is recommended. Recurrence rates for benign, borderline and malignant phyllodes tumors are %17, %25, %27, respectively (4,5). Malignant transformation of the tumor usually occurs in the stromal part of the tumor but the epithelial component of phyllodes tumors can transform into a malignancy too (6).…”

Section: Introductionmentioning

confidence: 99%

In Situ Ductal Carcinoma Arising in Benign Phyllodes Tumor in 19-Year Old Patient: A Case Report

et al. 2014

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Phyllodes tumors are fibroepithelial lesions and malign forms are rare neoplasms with lower than 1% of all primary breast tumors. Malign forms are usually behaves like sarcomas because they occur in the stroma of the breast. Also proliferation of epithelium occurs and even it is less often, the epithelial component of phyllodes tumors can transform into malignancy too. This epithelial malignancies are usually in the form of infiltrative carcinomas and non-invasive tumors arising in benign phyllodes tumors are much rarer but can be seen. Literature include very few cases about this situation and cases are usually old woman. We report a 19-year old patient who was diagnosed with ductal carcinoma in situ arising in benign phyllodes tumor of the breast.

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“…Nomura et al (7) reported that mammography revealed a welldefined tumor with a diameter of 3.3 cm, and US revealed a tumor with a regular border and low echogenicity. Yamaguchi et al (8) described the tumor as a mixed cystic and solid mass on US and magnetic resonance imaging. There are no specific clinical or radiologic clues to indicate the presence of in situ carcinoma within a phyllodes tumor (2).…”

Section: Index Termsmentioning

confidence: 99%