Ductal carcinoma<i>In situ</i>: The challenges and approaches

Agrawal, Sujan Narayan

doi:10.4103/2278-9596.202366

Cited by 1 publication

(3 citation statements)

References 2 publications

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“…It accounts for 20-25% of breast cancer [3,4,6,7]. There has been a rising trend of DCIS due to utilization of breast cancer screening mammography which can be detected as microcalcification without a palpable lump [8].…”

Section: Incidence Of Dcismentioning

confidence: 99%

“…Microinvasive breast cancer is defined as invasion of tumor cells singly or in clusters into stroma and invasive focus measuring not more than 1 mm in its greatest dimension [1,[3][4][5]10]. It accounts for 13.5% of DCIS cases [11] and less than 1% of breast cancer cases [1,11].…”

Section: Dcis With Microinvasion or Microinvasive Dcismentioning

confidence: 99%

“…Ductal carcinoma in-situ (DCIS) is the most common noninvasive malignancy of the breast. It is defined as proliferation of malignant cells in ductal epithelium confined to basement membrane, not invading the breast parenchyma [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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The Study of Ductal Carcinoma In Situ (DCIS) with Microinvasion Using Myoepithelial Markers

Sana¹,

Anjaneyulu²,

Daphne³

et al. 2018

Int J Pathol Clin Res

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Background: DCIS is a premalignant condition characterized by proliferation of neoplastic cells within the ducts with intact myoepithelial cell layer and when there is a breach in myoepithelial cell layer it indicates invasion and in both these condition treatment protocols and prognosis is different. Myoepithelial markers can be used to identify breach and hence invasion.Aim: To identify DCIS with microinvasion using SMA, calpopin and p63 by IHC.Methods: This is a retro-prospective observational study with study population of 100 conducted in the department of pathology, Basavatarakam Indo-American cancer hospital and research institute over a period of one year from January 2015 to December 2016 as per inclusion criteria. Suspected cases of DCIS with microinvasion and focal invasion on H&E sections by morphological features is identified. Panel of IHC markers with SMA, calponin and p63 on the suspected cases is performed and efficiency of IHC markers with H&E in detecting microinvasive and focal invasive component is compared. The sensitivity and specificity of IHC markers studied. Results:The three groups i.e. DCIS, DCIS with microinvasion and DCIS with invasion constitutes 22%, 7% and 71% respectively.This study aims to utilize three myoepithelial markers, SMA, calponin and p63 in differentiating extensive DCIS and DCIS with microinvasion and focal invasion. Aim and Objectives AimTo identify DCIS with microinvasion using SMA, calponin and p63 by IHC. Objectives Primary objectives:1. Identify the suspected cases of DCIS with microinvasion and focal invasion on H&E sections by morphological features.2. Perform a panel of IHC markers with SMA, calponin and p63 on the suspected cases.3. Compare the efficiency of IHC markers with H&E in detecting microinvasive and focal invasive component.Secondary objective: Compare the sensitivity and specificity of IHC markers studied.

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