Duck wastes as a potential reservoir of novel antibiotic resistance genes

The overuse of antibiotics in food animals has led to the development of bacterial resistance and the widespread of resistant bacteria in the world. Antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARGs) in food animals are currently considered emerging contaminants, which are a serious threat to public health globally. The current situation of ARB and ARGs from food animal farms, manure, and the wastewater was firstly covered in this review. Potential risks to public health were also highlighted, as well as strategies (including novel technologies, alternatives, and administration) to fight against bacterial resistance. This review can provide an avenue for further research, development, and application of novel antibacterial agents to reduce the adverse effects of antibiotic resistance in food animal farms.

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“… Wang X.R. et al (2021) determined the diversity of ARGs from duck wastes by using the metagenomic method.…”

Section: Bacterial Resistance To Antibiotics In Food Animal Manurementioning

confidence: 99%

“…These novel ARGs were related to either hydrolyzation of both penicillins and cephalosporins or MGEs. Noticeably, the MICs of E. coli carrying fosA-like genes increased by 128-fold, indicating a key resistome reservoir in duck farms and posing a high spread risk ( Wang X.R. et al, 2021 ).…”

Section: Bacterial Resistance To Antibiotics In Food Animal Manurementioning

confidence: 99%

A Review of Current Bacterial Resistance to Antibiotics in Food Animals

Kong

Gao

et al. 2022

Front. Microbiol.

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“…It is of high interest to elucidate how animal husbandry bridges the gap between the environmental and human microbiome. Previous studies spotlighted that, via animal products and wastes, frequent microbial exchange between the environment and humans occurred as a result of complex interplays between the environment, animals, and humans ( Téllez et al, 2015 ; Wang et al, 2021 ). As a result, antibiotic resistance genes (ARGs) of clinical importance might spread in tandem with such microbial exchanges, thereby posing a direct threat to public health ( Xu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure in swine farm defines human skin and nasal microbiota

Wang

Chen

et al. 2023

Front. Microbiol.

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Anthropogenic environments take an active part in shaping the human microbiome. Herein, we studied skin and nasal microbiota dynamics in response to the exposure in confined and controlled swine farms to decipher the impact of occupational exposure on microbiome formation. The microbiota of volunteers was longitudinally profiled in a 9-months survey, in which the volunteers underwent occupational exposure during 3-month internships in swine farms. By high-throughput sequencing, we showed that occupational exposure compositionally and functionally reshaped the volunteers’ skin and nasal microbiota. The exposure in farm A reduced the microbial diversity of skin and nasal microbiota, whereas the microbiota of skin and nose increased after exposure in farm B. The exposure in different farms resulted in compositionally different microbial patterns, as the abundance of Actinobacteria sharply increased at expense of Firmicutes after exposure in farm A, yet Proteobacteria became the most predominant in the volunteers in farm B. The remodeled microbiota composition due to exposure in farm A appeared to stall and persist, whereas the microbiota of volunteers in farm B showed better resilience to revert to the pre-exposure state within 9 months after the exposure. Several metabolic pathways, for example, the styrene, aminobenzoate, and N-glycan biosynthesis, were significantly altered through our PICRUSt analysis, and notably, the function of beta-lactam resistance was predicted to enrich after exposure in farm A yet decrease in farm B. We proposed that the differently modified microbiota patterns might be coordinated by microbial and non-microbial factors in different swine farms, which were always environment-specific. This study highlights the active role of occupational exposure in defining the skin and nasal microbiota and sheds light on the dynamics of microbial patterns in response to environmental conversion.

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“…Furthermore, Salmonella alters the expression of toll-like receptors, NOD-like receptors, β-defensins, and cytokine family genes in the oviduct, resulting in the decline of egg quality ( Zhang et al, 2019 ). Studies have shown that duck excrement contains a large number of different pathogenic bacteria ( Jeong et al., 2021 ; Wang et al, 2021 ), which will affect the composition of litter microorganisms in the duck house. It has a certain impact on the health of ducks and egg quality.…”

Section: Introductionmentioning

confidence: 99%