Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

Hei, Mingyang; Wang, Jun; Wang, Kelly; Zhu, Weiping

doi:10.1039/c7tb02429k

Cited by 33 publications

(20 citation statements)

References 40 publications

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“…The behavior of LCST polymers in these systems suggests that UCST polymers may be a better choice of thermo-responsive gatekeepers. Hei et al conjugated poly(acrylamide-co-acrylonitrile) onto an MSN via a disulfide bond [ 571 ]. Under the UCST, the polymer collapsed into globular morphology and blocked the pores on MSN, while above the transition temperature, it converted to a random coil state and released the payload.…”

Section: Stimulimentioning

confidence: 99%

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Sun

Davis

2021

Nanomaterials

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To achieve the promise of stimuli-responsive drug delivery systems for the treatment of cancer, they should (1) avoid premature clearance; (2) accumulate in tumors and undergo endocytosis by cancer cells; and (3) exhibit appropriate stimuli-responsive release of the payload. It is challenging to address all of these requirements simultaneously. However, the numerous proof-of-concept studies addressing one or more of these requirements reported every year have dramatically expanded the toolbox available for the design of drug delivery systems. This review highlights recent advances in the targeting and stimuli-responsiveness of drug delivery systems. It begins with a discussion of nanocarrier types and an overview of the factors influencing nanocarrier biodistribution. On-demand release strategies and their application to each type of nanocarrier are reviewed, including both endogenous and exogenous stimuli. Recent developments in stimuli-responsive targeting strategies are also discussed. The remaining challenges and prospective solutions in the field are discussed throughout the review, which is intended to assist researchers in overcoming interdisciplinary knowledge barriers and increase the speed of development. This review presents a nanocarrier-based drug delivery systems toolbox that enables the application of techniques across platforms and inspires researchers with interdisciplinary information to boost the development of multifunctional therapeutic nanoplatforms for cancer therapy.

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Section: Stimulimentioning

confidence: 99%

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Sun

Davis

2021

Nanomaterials

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“…While water-soluble polymers with a LCST have been widely studied [3][4][5][6][7], those with an UCST are more rare despite the recent increasing interest they received [8,9]. UCST polymers find applications in biomedicine [10] such as drug delivery [11][12][13], catalysis [14] and 3D-printed scaffolds [15]. This UCST behavior is promoted by either hydrogen bonding or Coulomb interactions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Zydziak

Iqbal

Chaumont

et al. 2020

European Polymer Journal

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Thermoresponsive polymers, undergoing a reversible chemical or physical change using temperature as stimulus, attract increasing interest in particular as adaptable biomaterials. Except for zwitterionic polymers, fully charged polymers require the presence of specific ions to exhibit an upper critical solution temperature (UCST) in water. Herein, we report the discovery of an UCST in pure water for fully cationic comb polymers based on oligoarginine pendent grafts. These polymers were prepared using an original strategy based on solid-phase peptide synthesis of pentaarginine methacrylate-based macromonomer and its polymerization through reversible addition-fragmentation chain transfer. Despite their cationic nature, guanidinium groups from the arginine have the ability to self-associate at low temperature through hydrophobic interactions into stacked pair configuration defying the expected Coulomb interactions. These results pave the way to biomedical applications such as antimicrobial materials and drug delivery systems through the tuning of the polymer structure.

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“…Similarly, P(AAm-co-AN) copolymer with UCST~ 42°C was grafted onto mesoporous silica nanoparticles (MSNs) via disulfide linkages, which acted as a gate and offered dual responsive (thermal and redox) controlled release of DOX from the MSN pores. Intracellular release of DOX in SK-BR-3 breast cancer cells was controlled successfully by varying temperature and by addition of reducing agent (DTT) as evident by in-vitro experiments ( Figure 16) [63]. Similarly, UCST polymer PEG-gpoly (AAm-co-AN) and poly(N-acryloyl glycine) were also utilized as coating material for magnetic nano particles to generate multiresponsive drug delivery carriers for temperature regulated release of cargo [64,65].…”

Section: Controlled Drug Releasementioning

confidence: 89%

Advances in thermo-responsive polymers exhibiting upper critical solution temperature (UCST)

Bansal¹,

Upadhyay²,

Saraogi³

et al. 2019

Express Polym. Lett.

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Immense work has been conducted in the field of thermoresponsive polymers specifically of lower critical solution temperature (LCST) type, but upper critical solution temperature (UCST) type polymers remain a significantly unexplored domain. However, in recent years, UCST polymers have attracted increased attention as evidenced by the rise in publications in the same domain, and therefore, this review is an attempt to compile the reported UCST-type polymers. Unlike LCST, UCST polymers are insoluble at low temperature but solubilize in a given solvent as the temperature increases. The synthesis approaches and applications of reported UCST polymers are discussed in this article. Emphasis has been given to the polymers exhibiting UCST behavior in aqueous medium, due to the obvious advantage of their wide applicability. It is quite apparent from this study that the attempts to synthesize novel polymers and copolymers exhibiting UCST has faced an upsurge, but their application part still requires considerable attention. Figure 4. (a) Representative structure of poly(acrylamide-co-acrylonitrile) and (b) turbidity cooling curves of poly(AAmco-AN) with different acrylonitrile content in mole% (numbers in graph). Reproduced with permission from [33],

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Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

Cited by 33 publications

References 40 publications

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains

Advances in thermo-responsive polymers exhibiting upper critical solution temperature (UCST)

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