Duality of Hepatitis B Antigen and Its Antibody: I. Immunofluorescence Studies

Brzosko, W. J.; Madaliński, K; Krawczyński, K.; Nowosławski, A

doi:10.1093/infdis/127.4.424

Cited by 72 publications

(19 citation statements)

References 8 publications

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“…In contrast, hyperimmune serum prepared against purified HB* Ag produced immunofluorescent staining exclusively in the cytoplasm of these cells. Thus, it appeared that HB, Ag (or antigens associated with it) was synthesized in the nucleus of the infected liver cell, and HBsAg was produced in the cytoplasm of these cells, a finding in good agreement with indirect immunofluorescence studies of Brzosko et al [4], One interpretation of the findings is that the spherical and filamentous forms of HBsAg may, in fact, consist of Dane particle coat components, synthesized in marked excess by the infected cell.…”

supporting

confidence: 85%

Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to It

et al. 1973

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A radioimmunoassay for detecting the core of the Dane particle and antibody to it was developed. The core was detected in concentrates of Dane particles but not in preparations of purified 22-nm forms of hepatitis B antigen. Detergent treatment of Dane particles increased the detectability of the core. Antibody to the core appeared following acute type B hepatitis infection and could be consistently demonstrated in chronic carriers of hepatitis B antigen. Such antibody was found less frequently in patients with evidence of re-exposure to hepatitis B antigen; it could not be detected in pooled hepatitis B immune serum globulin.

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supporting

confidence: 85%

Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to It

et al. 1973

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“…The Clq agar gel precipitation test has been used earlier for the detection of HB-Ag-antibody complexes in patients suffering from polyarteritis nodosa (19). It has been suggested that the HB-Ag virus forms complexes with its specific antibody, either at the site of the injury (49) or in blood (8,43 …”

mentioning

confidence: 99%

Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq

Nydegger¹,

Lambert²,

Gerber³

et al. 1974

J. Clin. Invest.

386

107

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“…In the present work we report results of clinical, biochemical, and immunological follow-up studies of a group of anti-HBs car riers described in a previous paper [2], [1].…”

Section: Introductionmentioning

confidence: 85%

Follow-Up Studies of Healthy Blood Donors. Anti-HBs Antibody Carriers

Ślusarczyk¹,

Cianciara²,

Świderska³

et al. 1981

Vox Sanguinis

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10 healthy blood donors persistently seropositive for anti-HBs and without a history of clinically overt viral hepatitis were observed for periods of time ranging from 46 to 57 months. Physical examinations and biochemical liver function tests were normal in all cases. Immunologic studies of their immune response to hepatitis B virus antigens are suggestive for a late period of convalescence from clinically inapparent hepatitis B.

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Duality of Hepatitis B Antigen and Its Antibody: I. Immunofluorescence Studies

Cited by 72 publications

References 8 publications

Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to It

Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to It

Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq

Follow-Up Studies of Healthy Blood Donors. Anti-HBs Antibody Carriers

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