This paper aims to describe some of the current literature on work breaks and to discuss important issues related to work breaks for keyboard operators. The relationship between work breaks and fatigue is examined, as well as the relationship between fatigue and injury. From the present literature available, there is no evidence to support any particular work/rest regime to reduce fatigue. Physiological studies support the concept of short frequent pauses (micropauses) as being the most effective way of reducing neuromuscular fatigue. No universal regime will be suitable for every keyboard situation. Prescribed regimented work breaks have many disadvantages and should be avoided if possible in favour of work breaks that are spontaneous or designed into the work.