Abstract:Most smokers who use electronic cigarettes (e-cigarettes) to stop smoking simultaneously use conventional cigarettes (dual users). We aimed to compare the prevalence of cardiovascular risk factors among dual users, cigarette-only smokers, and never smokers in Korean men. We used data acquired from Korean National Health and Nutrition Examination Survey (2013–2017) pertaining to 7,505 male participants aged 19 years or older. About 85% of e-cigarette users were dual users. Dual users had greater nicotine depend… Show more
“…An analysis of the NHANES data also demonstrated no correlation between decreased sensitivity of tissues to insulin and different types of smokers (conventional cigarettes smokers, e-cigarettes users, dual users and nonsmokers) [44]. A lack of significant differences in the level of glucose was demonstrated also by Kim et al [37] in their aforementioned study.…”
Section: Insulin Resistancementioning
confidence: 76%
“…The obtained results allowed the researchers to claim that the occurrence of MetS was connected with using e-cigarettes, whenever patients were not on a diet. Another study [ 37 ] has been conducted on a group of 7505 Korean males over 19 years of age to compare the frequency of occurrence of cardiovascular risk factors among: males smoking conventional cigarettes, dual users (e-cigarettes and traditional cigarettes users) and never-smokers. The multivariate logistic regression analysis showed that, in the adjusted model, the odds ratio (OR) for the prevalence of MetS equaled 2.79 ( p < 0.001) in comparison with never-smokers and 1.57 ( p = 0.038) in relation to cigarette-only smokers [ 37 ].…”
Section: E-cigarettes and Metabolic Syndromementioning
The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.
“…An analysis of the NHANES data also demonstrated no correlation between decreased sensitivity of tissues to insulin and different types of smokers (conventional cigarettes smokers, e-cigarettes users, dual users and nonsmokers) [44]. A lack of significant differences in the level of glucose was demonstrated also by Kim et al [37] in their aforementioned study.…”
Section: Insulin Resistancementioning
confidence: 76%
“…The obtained results allowed the researchers to claim that the occurrence of MetS was connected with using e-cigarettes, whenever patients were not on a diet. Another study [ 37 ] has been conducted on a group of 7505 Korean males over 19 years of age to compare the frequency of occurrence of cardiovascular risk factors among: males smoking conventional cigarettes, dual users (e-cigarettes and traditional cigarettes users) and never-smokers. The multivariate logistic regression analysis showed that, in the adjusted model, the odds ratio (OR) for the prevalence of MetS equaled 2.79 ( p < 0.001) in comparison with never-smokers and 1.57 ( p = 0.038) in relation to cigarette-only smokers [ 37 ].…”
Section: E-cigarettes and Metabolic Syndromementioning
The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.
“…Further, we found that dual use had detrimental effects on the participants, whereby dual users reported experiencing chest wheezing, sputum production, and cough more often than did EC-only users. Similarly, a study among 7505 males found dual users to be more nicotine-dependent as compared to cigarette-only smokers [ 31 ].…”
Background
E-cigarette (EC) use is increasing worldwide. Understanding the practices and perceptions of e-cigarette users and profiling the symptoms they experience is essential for regulating the use of such products. This study aims to investigate the practices and perceptions of e-cigarette users in Jordan and examine the symptoms (e.g. respiratory) they associate with e-cigarette use.
Methods
A cross-sectional online survey was conducted to assess EC use and tobacco smoking behaviors and the corresponding health symptoms among EC users in Jordan. EC use expectancies were also assessed using the Short Form Vaping Consequences Questionnaire, which was first translated into Arabic and tested for validity and reliability.
Results
Out of the 400 EC users surveyed, 95.5% were male, 76.2% used nicotine-containing juice, and 56.8% were concurrent tobacco smokers. Further, the participants had a mean age of 28.9 years (±10.2). Among dual EC/cigarette users, 88.6% reported that they tried to quit cigarette smoking, with e-cigarette use being the most commonly tried method of smoking cessation. The smoking-related symptoms reported by regular cigarette smokers mainly included sputum production (77.5%). The participants reported that using e-cigarettes instead of tobacco cigarettes had led to improvements in their sputum production (60.8%), breathing (59%), and general wellbeing (52%). Pleasant taste, enjoyable taste sensation, and flavor were significantly stronger (P-value < 0.05) among e-cigarette users compared to dual users. Dual EC/cigarette users reported stronger perceptions in the negative consequences scale, particularly with regards to the hazardous effects of smoking on health (P-value < 0.05).
Conclusion
Dual daily use of e-cigarettes and regular cigarettes is a common practice among EC users. We recommend that further research is conducted on dual EC/cigarette use and the potential health risks this may have (e.g. higher nicotine intake as compared to the single use of either products).
“…They concluded that in dual users of conventional cigarette and e-cigarette, the use of e-cigarettes was not associated with less exposure to tobacco smoke or health risks [ 16 ]. On the other hand, Kim et al reported that dual users had greater nicotine dependence and higher urinary cotinine levels than cigarette-only smokers [ 17 ].…”
Background: Cigarette smoking is an important risk factor for cardiac diseases. In the current study, we sought to assess the effect of electronic cigarette extract (ECE) and conventional cigarette smoke extract (CSE) on cardiomyocytes. Methods: iPSCs-derived cardiomyocytes were used in the study to evaluate cellular toxicities. Cells were exposed to either ECE or CSE for two consecutive days as an acute exposure or every other day for 14 days. Concentration of nicotine in both ECE and CSE were measured by Mass-Spectrometry and Q-Exactive-HF was used to identify other ingredients in both extracts. Fluorescent microscopy was used to measure the oxidative stress after ECE and CSE exposure. Motility and beat frequency of cardiomyocytes were determined using the Sisson-Ammons Video Analysis system. Heart failure target panel genes of exposed cardiomyocytes were compared to control unexposed cells. Results: Despite nicotine concentration in CSE being six-fold higher than ECE (50 μg in CSE and 8 μg in ECE), ECE had similar toxic effect on cardiomyocytes. Both CSE and ECE generate significant cellular reactive oxygen species. The Sisson-Ammons Video Analysis (SAVA) analysis showed significant changes in myocyte function with both CSE and ECE slowing beating and increasing cell death. Chronic exposure of both ECE and CSE significantly decreased cardiomyocytes viability long term at all doses. Target panel gene expression profiles of both ECE and CSE exposed cardiomyocytes were different from controls with distinct pattern of genes that involved cell proliferation, inflammation, and apoptosis.
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