Dual time point 2-[18F]fluoro-2′-deoxyglucose positron emission tomography in chronic bacterial osteomyelitis

Abstract

Our preliminary results indicate that dynamic dual time point F-FDG PET provides a characteristic pattern in chronic osteomyelitis similar to inflammatory processes in other locations. This pattern may be of value in the differentiation between COM and malignant bone lesions.

Differentiation of FDG-avid loco-regional recurrent and compromised benign lesions after surgery for breast cancer with dual-time point F-18-fluorodeoxy-glucose PET/CT scan

“…A longer time interval after surgery may reduce the number of false positives, as the majority of the present false positives were determined at a relatively early time (within 2-3 months) after surgery. Previous studies rarely showed a prolonged increase of FDG uptake in the chronic phase of inflammatory lesions or post-operative scars [9,21,23,34,41]. FDG uptake kinetics in inflammatory lesions should be altered according to the predominant inflammatory cells involved and the extent of activation of these cells.…”

Limited diagnostic and predictive values of dual-time-point 18F FDG PET/CT for differentiation of incidentally detected thyroid nodules

“…Besides the malignant diseases, this interesting acquisition method of 18 F FDG PET imaging was applied to investigate glucose metabolism in chronic bacterial osteomyelitis [21]. Moreover, other radiopharmaceuticals with the same acquisition method were used for similar purposes in various conditions [22,23].…”

Nuclear medicine techniques: a better weapon in detecting a rare case of epiphyseal osteomyelitis caused by Salmonella in a patient without sickle cell disease

“…In particular, 18F-FDG PET/CT was demonstrated to be accurate and rapid in identifying the presence or absence of an infective source in selected cases 10 , with high negative predictive value 11 . The singular advantage of F-18 FDG PET over MRI is the ability to monitor quantitatively the response to antimicrobial treatment.…”

“…Conversely, nuclear medicine imaging can be useful for diagnosing and monitoring Salmonella bone lesions, giving more information than conventional imaging 5,6 . We here present a very unusual case of osteomyelitis caused by Salmonella typhi in a non-sickle cell patient, whose diagnosis could be obtained only with nuclear medicine imaging.…”