Dual Therapy Versus Monotherapy in the Endoscopic Treatment of High-Risk Bleeding Ulcers: A Meta-Analysis of Controlled Trials

Marmo, Riccardo; Rotondano, G.; Piscopo, Roberto; Bianco, Maria Antonia; D'Angella, R.; Cipolletta, Livio

doi:10.1111/j.1572-0241.2006.01023.x

Cited by 243 publications

(149 citation statements)

References 49 publications

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“…We consider that the P-value is related to the small sample size in our study. Therefore we recommend that if epinephrine is going to be used, it is necessary to apply double ET, which could be considered an extrapolation of the recommendations for peptic ulcer treatment [Marmo et al 2007]. A comparison was made between mechanical (hemoclips and rubber band ligation) vs thermal therapy, and regarding response to ET, no differences were found (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal Dieulafoy's lesions and endoscopic treatment: First report from a Mexican centre

López-Arce

Zepeda-Gómez

Chávez-Tapia

et al. 2008

Therap Adv Gastroenterol

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Abstract:The aim was to evaluate the initial success, rebleeding rate, need for emergent surgery, and mortality rates of patients with Dieulafoy's lesion (DL) and endoscopic treatment (ET). Patients with DL from a tertiary center were included. We included 20 patients with follow-up of 90 (60-550) days. The lesser curvature was the most common localization. Initial success, rebleeding, and emergent surgery requirement were observed in 90%, 10%, and 15%, respectively. No objective variables were related with response to ET. In conclusion, ET is secure and useful in patients with DL and it must be considered as the first-line treatment modality.

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Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal Dieulafoy's lesions and endoscopic treatment: First report from a Mexican centre

López-Arce

Zepeda-Gómez

Chávez-Tapia

et al. 2008

Therap Adv Gastroenterol

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“…Entretanto, a terapia combinada não apresentou vantagens quando comparada à monoterapia com termocoagulação ou hemoclipes adequadamente aplicados. 23 Quanto 24 Peng et al em um estudo retrospectivo, comparou 110 pacientes que receberam terapia com plasma de argônio a 84 pacientes tratados com hemoclipe. Não houve diferença estatística quanto a taxa de ressangramento, mortalidade, cirurgia, e necessidade de hemotransfusão.…”

Section: Termocoagulaçãounclassified

Modalidades De Terapia Endoscópica Frente À Hemorragia Digestiva Alta Não-Varicosa

Sakuragi¹,

Bergamasco²,

Merlini³

2015

Bjim

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RESUMOA hemorragia digestiva alta não-varicosa ainda é uma frequente emergência médica, em especial nos pacientes com doença ulcerosa péptica. Estima-se uma incidência de até 99 casos por ano em 100.000 habitantes. Os locais de sangramento compreendem o esôfago, o estômago e o duodeno -porção acima do ligamento de Treitz. Embora a maioria dos episódios cesse espontaneamente, uma parcela expressiva de pacientes necessita de intervenção endoscópica. O presente estudo objetiva revisar as modalidades de terapia disponíveis por meio de endoscopia digestiva alta: injetáveis, termocoagulação, mecânicas, e mais recentemente, o hemospray; e dessa forma, avaliar a eficácia em termos de hemostasia, bem como as taxas de ressangramento e complicações. PALAVRAS-CHAVE: hemorragia digestiva alta não-varicosa; endoscopia digestiva alta; hemostase endoscópica. ABSTRACTThe nonvariceal upper gastrointestinal bleeding remains a common medical emergency, especially in patients with peptic ulcers. There is estimated an incidence of up 99 cases per year in 100.000 inhabitants. The sites of bleeding include the esophagus, stomach and duodenum -the portion above the ligament of Treitz. Although most episodes cease spontaneously, a significant proportion requires endoscopic intervention. This study aims to review the available modalities of endoscopic therapies: injection, thermocoagulation, mechanical, and more recently, hemospray; and thus, evaluate the effectiveness in terms os hemostasis, as well as the rates of rebleeding and complications.

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“…However, it had no advantage over thermal or mechanical monotherapy to improve the outcome of patients with high-risk peptic ulcer bleeding (Marmo et al 2007). When combining injected substances with thermal coagulation in bleeding peptic ulcer disease, there is a significant risk of complications such as perforation and gastric wall necrosis.…”

Section: Control Of Active Bleeding or High-risk Lesionsmentioning

confidence: 99%

Management of Acute Gastric Ulcer Bleeding

Rensburg¹,

Marais²

2011

Peptic Ulcer Disease

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Dual Therapy Versus Monotherapy in the Endoscopic Treatment of High-Risk Bleeding Ulcers: A Meta-Analysis of Controlled Trials

Abstract: Dual endoscopic therapy proved significantly superior to epinephrine injection alone, but had no advantage over thermal or mechanical monotherapy in improving the outcome of patients with high-risk peptic ulcer bleeding.

Cited by 243 publications

References 49 publications

Upper gastrointestinal Dieulafoy's lesions and endoscopic treatment: First report from a Mexican centre

Upper gastrointestinal Dieulafoy's lesions and endoscopic treatment: First report from a Mexican centre

Modalidades De Terapia Endoscópica Frente À Hemorragia Digestiva Alta Não-Varicosa

Management of Acute Gastric Ulcer Bleeding

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