Dual-Targeting Nanoplatform Based on Rolling Circle Amplification for Enhanced Multimodal Synergistic Treatment of Breast Cancer
Xiaobing Huo,
Zhiqing Zhang,
Huan Du
et al.
Abstract:We present a rolling circle amplification (RCA)-based
nanoplatform
that integrates dual-targeting, photothermal therapy (PTT), chemodynamic
therapy (CDT), gene therapy (GT), and chemotherapy (CT) for synergistic
breast cancer therapy. First, RCA-assembly (RA) was constructed by
integrating RCA and three single-stranded DNA (ssDNA) with different
functions (S2.2 aptamer chain, 17-E DNAzyme chain, and carboxyl chain).
Then, RA-Dox (RD) was further constructed based on the property of
doxorubicin (Dox) autonomous… Show more
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