Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes

Lu, Yu-Jen; Wei, Kuo-Chen; Chen‐Chi, M.; Yang, Shao-Ming; Chen, Jyh‐Ping

doi:10.1016/j.colsurfb.2011.08.001

Cited by 204 publications

(93 citation statements)

References 54 publications

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“…[22][23][24][25][26][27][28][29] Zhang et al 13 developed a targeted delivery system using FA-tethered SWCNT-DOX. This system employed polysaccharides (sodium alginate and CS) to control the release of DOX, while FA was used to improve the targeting properties of CNTs.…”

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confidence: 99%

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Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

216

106

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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confidence: 99%

“…They also developed a CNT-based magnetic dual-targeted nanocarrier for drug delivery. 24 Their magnetic MWCNTs were conjugated to the targeting ligand FA to load the anticancer drug DOX. Under the guidance of a magnetic field and ligand receptor interactions, dualtargeted delivery of DOX into cancer cells was successfully performed.…”

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confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

216

106

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“…It has been reported that the surfaces of U87 cells show overexpression of the folate receptor (FR), which has been used to develop FA-mediated targeting chemotherapy. 2 The prepared nanoparticles (FARIPNPs) demonstrate great biocompatibility and stability, in addition to prolonging the blood circulation of RSV and ICG. In addition, FA-RIPNPs were used as NIR probes to monitor the cell internalization, in vivo biodistribution and tumor accumulation of RSV.…”

Section: Introductionmentioning

confidence: 99%

“…However, serious side effects and poor survival rates are associated with the therapy of this cancer type. 2 A precise diagnosis for surgical excision and targeted chemotherapy with minimal side effects are critical, albeit unmet, scientific goals and an ideal strategy in the treatment of glioma. Near-infrared (NIR) fluorescence imaging, combined with an actively targeting probe with high sensitivity, imaging speed and tumortargeted imaging effect, has been developed as a promising approach for the precise and intraoperative identification of tumor margins.…”

Section: Introductionmentioning

confidence: 99%

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

Xin

Yang

2016

IJN

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“…Which primary usually delivered anticancer drug to the diseased tissue, then to the tumors with some targeting moieties (Petkau et al, 2011). For example, the conjugate of doxorubicin with multi-walled carbon nanotubes as a brain targeting agent and folic acid (FA) targeting as a tumor targeting agent had dual-targeting function (Lu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%