Dual stimulus responsive drug release under the interaction of pH value and pulsatile electric field for a bacterial cellulose/sodium alginate/multi-walled carbon nanotube hybrid hydrogel

Shi, Xiangning; Zheng, Yudong; Cai, Wei; Yue, Lina; Qiao, Ke; Wang, Guojie; Wang, Luning; Quan, Haiyu

doi:10.1039/c5ra04897d

Cited by 48 publications

(18 citation statements)

References 43 publications

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“…Macroscale triggerable systems that can release drug via the triggering of externally applied physical signals, such as ultrasound, temperature, electric, magnetic fields, and light, are gaining attention in medicine. These triggerable drug delivery systems allow a spatiotemporal management of drug availability at a disease site controlled by the patient or physician using a remote device .…”

Section: Introductionmentioning

confidence: 99%

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Shademani

Zhang

Jackson

et al. 2016

Adv Funct Materials

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Triggerable devices capable of on‐demand, controlled release of therapeutics are attractive options for the treatment of local diseases because of their potential to enhance therapeutic effectiveness with reduced systemic toxicity. Here, the design and fabrication of a miniaturized device, termed a microspouter, is described. This device is shown to provide active and precise control of localized delivery of drugs on demand. The microspouter is composed of a magnetic sponge to provide the force for drug release through magnetic field‐induced reversible deformation, a reservoir for the sponge installation and drug loading, and a soft membrane for sealing the device. Following application of a magnetic field to the microspouter, the shrinking of the sponge may trigger a spouting of drug through a membrane's microaperture. The efficiency of the device in controlling the dose and time course of drug release under different external magnetic fields has been demonstrated using methylene blue and docetaxel as model drugs. Additionally, the microspouter is found to have low background drug leakage that allows for tunable drug release in an ex vivo implantation experiment. All the results confirm the microspouter as a potential device for safe, long‐time, and controlled drug release in local disease treatment.

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Section: Introductionmentioning

confidence: 99%

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Shademani

Zhang

Jackson

et al. 2016

Adv Funct Materials

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“…Carbon nanotubes (CNTs) have also been doped into hydrogels to improve the electrical conductivity for higher sensitivity (Figure H) . For hybrid hydrogels composed of sodium alginate and bacterial cellulose, a doping of 0.25 wt% CNTs could improve the conductivity for more than 6 times . An in vivo delivery and controllable release of drugs have been demonstrated with the CNTs doped hydrogels .…”

Section: Biochemical Release Controlled By Electrochemical Actuationmentioning

confidence: 99%

Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review

Guo

Fan

2018

ChemNanoMat

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To release biosubstances, including drug molecules, DNAs, and proteins, at prescribed cellular and tissue locations with controllable rates is the Holy Grail of drug delivery that could enable an array of unprecedented in vitro and in vivo applications. Extensive research efforts have been focused on exploring innovative mechanisms and approaches for controlling biochemical release with prescribed dose, timing, and dynamics. Particularly, the utilization of electric fields to stimulate the release of biomolecules from synthesized micro/nanostructures has received considerable interest. In this review, we focus on the recent progresses in controlling the release of biomolecules with electric fields by a variety of mechanisms, including electrochemical desorption and actuation, electrically triggered erosion, and electrically driven nanopumps and mechanical motions. The research on external electric stimuli trigged biorelease has progressed rapidly and could make remarkable impact in single‐cell biology, cell‐cell communication, and drug discovery.

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“…In the case of hybrid or composite hydrogels, polysaccharides can also be combined with proteins to assist with carbon nanostructure dispersibility, and it is expected that this trend to use different components in sophisticated biomaterial designs will perdure and be further refined in the future. The combination of multiple gelling agents with carbon nanostructures is a useful approach to control the material, and interesting properties can be obtained, e.g., dual stimulus responsive drug release under the interaction of pH value and pulsatile electric field [81].…”

Section: Future Directions Of Polysaccharide Hydrogelsmentioning

confidence: 99%

“…(8). Heparin (top) sulfonate and carboxylate functional groups can be mimicked by a combination of sodium styrene sulfonate polymer (bottom left) and GO (bottom right), respectively [81]. for hierarchical alignment of myoblasts and myotubes, in order to maximize contractility and force generation within engineered muscle tissue [105].…”

Section: Acrylate Polymersmentioning

confidence: 99%

The Glitter of Carbon Nanostructures in Hybrid/Composite Hydrogels for Medicinal Use

Iglesias¹,

Bosi²,

Melchionna³

et al. 2016

CTMC

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In recent years, we have witnessed to fast developments in the medicinal field of hydrogels containing various forms of integrated nanostructured carbon that adds interesting mechanical, thermal, and electronic properties. Besides key advances in tissue engineering (especially for conductive tissue, such as for the brain and the heart), there has been innovation also in the area of drug delivery on-demand, with engineered hydrogels capable of repeated response to light, thermal, or electric stimuli. This mini-review focusses on the most promising developments as applied to the gelation of protein/ peptide (including self-assembling amino acids and low-molecular-weight gelators), polysaccharide, and/or synthetic polymer components in medicine. The emerging field of graphene-only hydrogels is also briefly discussed, to give the reader a full flavor of the rising new paradigms in medicine that are made possible through the integration of nanostructured carbon (e.g., carbon nanotubes, nanohorns, nanodiamonds, fullerene, etc.). Nanocarbons are offering great opportunities to bring on a revolution in therapy that the modern medicinal chemist needs to master, to realise their full potential into powerful therapeutic solutions for the patient.

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Dual stimulus responsive drug release under the interaction of pH value and pulsatile electric field for a bacterial cellulose/sodium alginate/multi-walled carbon nanotube hybrid hydrogel

Abstract: Hydrogels synthesized by SA, BC and MWCNTs was a pH and electric responsive drug delivery system. The combination stimuli-releasing had selectivity for the pH value. Pulsatile releasing pattern was also had selectivity for the pH value.

Cited by 48 publications

References 43 publications

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review

The Glitter of Carbon Nanostructures in Hybrid/Composite Hydrogels for Medicinal Use

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