Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy

Abstract

Development of stimuli-responsive theranostics is of great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as cancer theranostic agents for multimodal imaging and chemo-photothermal combination therapy. The Bi-BSA NRs are synthesized in aqueous phase via a facile reduction method using Bi 2 O 3 nanospheres as the sacrificial template. The morphology, biocompatibility, photothermal effect, drug loading/releasing abilities, chemotherapy effect, synergistic chemo-photothermal therapy efficacy, and multimodal imaging capacities of Bi-BSA NRs have been investigated. The results show that the NRs possess multiple unique features including (i) raspberry-like morphology with high specific surface area (∼52.24 m 2 •g −1 ) and large cavity (total pore volume ∼0.30 cm 3 •g −1 ), promising high drug loading capacity (∼69 wt %); (ii) dual-stimuli responsive drug release, triggered by acidic pH and NIR laser irradiation; (iii) infrared thermal (IRT), photoacoustic (PA) and X-ray computed tomography (CT) trimodality imaging with the CT contrast enhanced efficiency as high as ∼66.7 HU•mL•mg −1 ; (iv) 100% tumor elimination through the combination chemo-photothermal therapy. Our work highlights the great potentials of Bi-BSA NRs as a versatile theranostics for multimodal imaging and combination therapy.

A RuII Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

“…Meanwhile,t he strong photothermal effect also provided ah igh IR thermal( IRT) imaging property ( Figure 3E). [16] The timedependentc ellular uptake of UiO-Ra-DOX-CuS NPs was determined by ICP-OESo ft he digested cell solutions.F igure S10 (in the Supporting Information) showst he increasing weight amount of Zr entering into the cells under different incubation times. [19] The DOX release behavior of UiO-Ra-DOX-CuS was investigated in PBS at different pH values (5.0 and 7.4).…”

“…After the loading of CuS, SEM and TEM images showedt hat the morphology of the MOF was not destroyed and the CuS NPs were uniformly dispersed on the surfaceo fU iO-Ra-DOX by electrostatic affinity ( Figure 1B). In addition, the zeta potential of UiO-Ra-DOX-CuS reduced from 5.6 mV to À2.3 mV ( After the functionalization of UiO-Ra with DOX, the characteristic DOX absorption peak at 498 nm shiftedt o5 10 nm on account of the DOX hydrophobicity transformation [16] ( Figure 2B)r evealed the expected elements dispersed uniformly,f urther confirming the successful preparation of UiO-Ra-DOX-CuS. 1 O 2 is consideredt ob et he main cytotoxic speciesi nP DT.…”

“…[15b] In addition, an enhanced DOX release was observed upon laser irradiation ( Figure 4B), indicating the laser-responsive drug release, andt he behavior of promotionald rug releasec ould be attributedt ot he photothermal effect of UiO-Ra-DOX-CuS, which would intensify thermal vibrations and facilitate DOX dissolution from the NPs. [16] The timedependentc ellular uptake of UiO-Ra-DOX-CuS NPs was determined by ICP-OESo ft he digested cell solutions.F igure S10 (in the Supporting Information) showst he increasing weight amount of Zr entering into the cells under different incubation times. This result could indicatet hat UiO-Ra-DOX-CuS NPs managed to be internalized into MDA-MB-231c ancerc ells through endocytosis.…”

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

“…The efficiency of CT contrast agent is improved by infrared thermal and PA. 100% tumor treatment rate was achieved by chemo-photothermal therapy. In conclusion, this Bi-BSA NRs have potential for the application of multimodality imaging and combination therapy [ 270 ] ( Figure 14 f).…”

PVP-coated Sb2Se3 nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows

“…In the light of the superiority of PTT in therapeutic modality, such as minimal invasiveness, noninvasive penetration and low toxicity, PTT has received increasing attention in recent years. [24][25][26][27][28][29][30][31][32][33][34][35] Photoacoustic imaging (PAI), which convert incident light into acoustic waves by exciting nanoparticle or chromophore with a strong optical absorbance spectrum in the NIR region, show powerful advantage such as deep tissue penetration, high spatial resolution, high signal-noise ratio in contrast to conventional X-ray computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI) and uorescence images (FLI). [36][37][38][39][40][41][42][43][44][45][46][47][48][49] In this work, we report a biocompatible PVP-coated Sb 2 Se 3 nanorods as PTT theranostic agents with relatively narrow band gap energy, which are responsive to the light (808 and 980 nm) in the NIR-I bio-windows (Scheme 1).…”