Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists

Peričić, Danka; Manev, Hari

doi:10.1007/bf01251007

J. Neural Transmission

1990

DOI: 10.1007/bf01251007

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Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists

Danka Peričić

Hari Manev

Abstract: The potential antidepressant dihydroergosine enhanced the convulsive properties of picrotoxin and bicuculline in rats and diminished them in mice. The possibility of dihydroergosine modulating species-dependently GABA/benzodiazepine receptors is suggested.

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1991

1993

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Cited by 6 publications

References 13 publications

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Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats

Pivac

Peričić

1993

J. Neural Transmission

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The acute intraperitoneal administration of anxiolytic diazepam (2 mg/kg) inhibits the activity of the hypothalamic-pituitary-adrenal (HPA) axis, i.e., it decreases the concentration of adrenocorticotropic hormone (ACTH) and corticosterone in female rats. This fall of ACTH and corticosterone levels was reversed by an antagonist of central benzodiazepine receptors-flumazenil. The antagonist of peripheral benzodiazepine receptors-PK 11195, failed to affect diazepam-induced decrement of plasma ACTH and corticosterone levels. The suppressed HPA function obtained after diazepam administration was also antagonized by bicuculline, an antagonist of GABA recognition sites, and by picrotoxin, a drug that blocks the GABA-A receptor associated chloride channel. These results suggest that central benzodiazepine receptors, the part of GABA-A macromolecular complex, are involved in diazepam-induced inhibition of the activity of the HPA axis.

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Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats

Pivac

Peričić

1993

J. Neural Transmission

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Species dependent effects of dihydroergosine on [3H]TBOB binding to membranes from the human, rat, bovine and mouse brain

Tvrdeić

Peričić

Cik

1992

J. Neural Transmission

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Dihydroergosine enhanced [3H]TBOB binding to the crude synaptosomal membranes prepared from the whole rat brain and human frontal cortex. Higher concentrations of the same drug inhibited [3H]TBOB binding in the preparations obtained from the whole mouse brain and bovine frontal cortex. Bicuculline-induced enhancement and GABA- or diazepam-induced inhibition of [3H]TBOB binding were similar in the four species examined. The results indicate that dihydroergosine modulates species-dependently GABA/benzodiazepine receptors.

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Dihydrogenfated ergot compounds bind with to GABAA receptor-associated Cl− ionophore

Tvrdeić¹,

Peričić²

1991

European Journal of Pharmacology

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Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists

Abstract: The potential antidepressant dihydroergosine enhanced the convulsive properties of picrotoxin and bicuculline in rats and diminished them in mice. The possibility of dihydroergosine modulating species-dependently GABA/benzodiazepine receptors is suggested.

Cited by 6 publications

References 13 publications

Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats

Inhibitory effect of diazepam on the activity of the hypothalamic-pituitary-adrenal axis in female rats

Species dependent effects of dihydroergosine on [3H]TBOB binding to membranes from the human, rat, bovine and mouse brain

Dihydrogenfated ergot compounds bind with to GABAA receptor-associated Cl− ionophore

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