Dual-Source Dual-Energy CT in Submandibular Sialolithiasis: Reliability and Radiation Burden

Pulickal, Geoiphy George; Singh, Dinesh; Lohan, Rahul; Chawla, Ashish

doi:10.2214/ajr.19.21299

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…Next to diagnostic benefits, DECT offers the chance of significant dose reduction, in particular by abolishing the obligation of a complete unenhanced scan due to reconstruction of virtual unenhanced images 3 – 7 . Nevertheless, comparative risk assessment of SECT and DECT should not only focus on radiation dose and dose rate, but also has to consider differences in biological effectiveness (BE) associated with varying photon energies 8 – 10 .…”

Section: Introductionmentioning

confidence: 99%

Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra

Kaatsch

Becker

Schüle

et al. 2021

Sci Rep

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Dual-energy CT provides enhanced diagnostic power with similar or even reduced radiation dose as compared to single-energy CT. Its principle is based on the distinct physical properties of low and high energetic photons, which, however, may also affect the biological effectiveness and hence the extent of CT-induced cellular damage. Therefore, a comparative analysis of biological effectiveness of dual- and single-energy CT scans with focus on early gene regulation and frequency of radiation-induced DNA double strand breaks (DSBs) was performed. Blood samples from three healthy individuals were irradiated ex vivo with single-energy (80 kV and 150 kV) and dual-energy tube voltages (80 kV/Sn150kV) employing a modern dual source CT scanner resulting in Volume Computed Tomography Dose Index (CTDIvol) of 15.79–18.26 mGy and dose length product (DLP) of 606.7–613.8 mGy*cm. Non-irradiated samples served as a control. Differential gene expression in peripheral blood mononuclear cells was analyzed 6 h after irradiation using whole transcriptome sequencing. DSB frequency was studied by 53BP1 + γH2AX co-immunostaining and microscopic evaluation of their focal accumulation at DSBs. Neither the analysis of gene expression nor DSB frequency provided any evidence for significantly increased biological effectiveness of dual-energy CT in comparison to samples irradiated with particular single-energy CT spectra. Relative to control, irradiated samples were characterized by a significantly higher rate of DSBs (p < 0.001) and the shared upregulation of five genes, AEN, BAX, DDB2, FDXR and EDA2R, which have already been suggested as radiation-induced biomarkers in previous studies. Despite steadily decreasing doses, CT diagnostics remain a genotoxic stressor with impact on gene regulation and DNA integrity. However, no evidence was found that varying X-ray spectra of CT impact the extent of cellular damage.

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Section: Introductionmentioning

confidence: 99%

Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra

Kaatsch

Becker

Schüle

et al. 2021

Sci Rep

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show abstract

“…Its boundary can be identified more accurately, which is beneficial to multi-parameter measurement and diagnosis of small lymph nodes with dual-energy CT. Small FOV, thinsection, and multi-planar reconstruction can help observe cervical LNs from different planes, detect more small LNs and discover more features in one LN, which help to diagnose metastatic LN (8). CARE Dose 4D or iterative reconstruction algorithm can reduce the radiation dose so that the radiation dose of CT at small FOV is not higher than that of CT at conventional FOV; dual-source dual-energy CT with energy spectrum purification technique reduces the radiation dose (10,11), leading to a 30% radiation dose reduction.…”

Section: Discussionmentioning

confidence: 99%

Dual-source dual-energy thin-section CT combined with small field of view technique for small lymph node in thyroid cancer: a retrospective diagnostic study

Zhuo

Sun

Chang³

et al. 2021

Gland Surg

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“…After using small FOV, the improved resolution is helpful to display internal features in these small lymph nodes. CARE Dose 4D or iterative reconstruction algorithm can reduce the radiation dose so that the radiation dose of CT at small FOV is not higher than that of CT at conventional FOV; dual-source dual-energy CT with energy spectrum puri cation technique, reduces the radiation dose [5,6] , leading to a 30% radiation dose reduction. Macrometastatic LNs must be treated, because it leads to worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Dual-Source Dual-Energy Thin-Section CT Combined with Small Field of View Technique for Diagnosing Small Lymph Node in Thyroid Cancer

Zhuo

Sun

Chang

et al. 2020

Preprint

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Background To evaluate the diagnostic performance of quantitative special CT parameters derived from dual-source dual-energy CT at small field of view (FOV) for small lymph node metastasis in thyroid cancer. Methods This was a retrospective study. From 2016 to 2019, 280 patients with thyroid disease underwent thin-section dual-source dual-energy thyroid CT and thyroid surgery. The data of patients with lymph nodes having a short diameter of 2-6 mm were analyzed. The targeted lymph nodes were sketched, their quantitative dual-energy CT parameters were measured, and all parameters between metastatic and nonmetastatic lymph nodes were compared. These parameters were then fitted to univariable and multivariable binary logistic regression models. The diagnostic role of spectral parameters was analyzed by receiver operating characteristic curves and compared with the McNemar test. Small FOV CT images and a mathematical model were used to judge the lymph nodes status respectively and then compared with pathological results.Results Of the 216 lymph nodes investigated in this study, 52.3% and 23.6% had a short diameter of 2-3 mm and 4 mm, respectively. Multiple quantitative CT parameters were found to be significantly different between benign and malignant lymph nodes and binary regression analysis was performed. The mathematical model was: p=ey/(1+ ey), y= = -23.119+0.033×precontrast electron cloud density+0.076×arterial phase normalized iodine concentration+2.156×arterial phase normalized effective atomic number -0.540×venous phase slope of the spectral Hounsfield unit curve +1.676×venous phase iodine concentration. This parameter model has an AUC of 92%, with good discrimination and consistency, and the diagnostic accuracy was 90.3%. The diagnostic accuracy of CT image model was 43.1%, and for lymph nodes with short-diameter 2-3 mm, the diagnostic accuracy was 22.1%.Conclusions Parameter model show higher diagnostic accuracy than CT image model for diagnosing small lymph node metastasis in thyroid cancer, and quantitative dual-energy CT parameters were very useful for small lymph nodes that were difficult to be diagnosed only on conventional CT images.Trial registration This study is retrospectively registered, and we have registered a prospective study (Registration number: ChiCTR2000035195;http://www.chictr.org.cn)

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Dual-Source Dual-Energy CT in Submandibular Sialolithiasis: Reliability and Radiation Burden

Cited by 12 publications

References 20 publications

Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra

Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra

Dual-source dual-energy thin-section CT combined with small field of view technique for small lymph node in thyroid cancer: a retrospective diagnostic study

Dual-Source Dual-Energy Thin-Section CT Combined with Small Field of View Technique for Diagnosing Small Lymph Node in Thyroid Cancer

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